Araiz-Iribarren, J. (Javier)

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    Effectiveness and safety of fluocinolone acetonide intravitreal implant in diabetic macular edema patients considered insufficiently responsive to available therapies (REACT): a prospective, non-randomized, and multicenter study
    (2023) Arias-Barquet, L. (L.); Garcia-Layana, A. (Alfredo); Durán, M.A. (Mónica Ascencio); Araiz-Iribarren, J. (Javier); Adan, A. (Alfredo); Lafuente, M. (María); Ruiz-Moreno, J.M. (José María)
    Objective: To assess the effectiveness and safety of the intravitreal fluocinolone-acetonide implant (FAc-i) in patients with chronic diabetic macular edema who did not sufficiently respond to other available therapies. Methods: This was a multicenter, prospective, non-randomized, and phase-IV observational study conducted on patients with recurrent-DME who were insufficient responders to currently available therapies (REACT-Study). The primary end-point was the mean change in best-corrected-visual-acuity from baseline to month-24 values. Results: Thirty-one eyes from 31 patients were included in the study. Mean age was 68.0 +/- 7.7 years, and 10 (32.3%) were women. Study patients had received 5.3 +/- 7.3 previous DME treatments before starting the study. In the overall study sample, BCVA improved from 56.1 +/- 12.3 letters at baseline to 62.4 +/- 17.0 letters at month-24 (p = 0.0510). The eyes with a baseline BCVA < 70 ETDRS letters had a significant improvement in BCVA from 53.2 +/- 10.2 letters at baseline to 61.5 +/- 17.9 letters at month-24 (p = 0.0165). In the overall study population, central-subfoveal-thickness (CST) was significantly reduced from 474.0 +/- 135.1 mu m at baseline to 333.4 +/- 135.6 at month-24 (p < 0.0001). Similarly, macular-volume (MV) was significantly reduced from 10.7 +/- 2.7 mm(3) at baseline to 9.6 +/- 2.9 mm(3) (p = 0.0027) at month-24. Among the 31 study eyes, 19 (61.3%) required an additional treatment for DME. Throughout the study, 9 (29.0%) eyes required ocular hypotensive medication for controlling their intraocular-pressure and 5 (16.1%) eyes underwent cataract surgery. Conclusions: In DME eyes who did not sufficiently respond to previous therapies, the FAc-i was associated with an improvement in visual and anatomic outcomes. There were no unexpected adverse-events.
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    Genetic and environmental factors related to the development of myopic maculopathy in Spanish patients
    (2020) González-Zamora, J. (Jorge); Arias, L. (Luis); Hernandez-Sanchez, M. (María); Maestre-Rellan, L. (Leyre); Velazquez-Villoria, A. (Alvaro); Llorente-González, S. (Sara); Garcia-Layana, A. (Alfredo); Fernández-Sanz, G. (Guillermo); Bilbao-Malavé, V. (Valentina); Berrozpe-Villabona, C. (Clara); Araiz-Iribarren, J. (Javier); Bezunartea, J. (Jaione); Carreño, E. (Ester); Fernandez-Robredo, P. (Patricia); Flores-Moreno, I. (Ignacio); Recalde, S. (Sergio); Ruiz-Moreno, J.M. (José María); Ruiz-Medrano, J. (Jorge)
    High myopia and the subsequent degenerative changes of the retina, choroid, and sclera, known as myopic maculopathy (MM), are a serious visual problem in many Asian countries, and are beginning to be so in the south of Europe, especially in the Mediterranean. It is therefore necessary to carry out genetic and environmental studies to determine the possible causes of this disease. This study aims to verify if the genetic factors that have been most related to Asian populations are also associated in two Spanish cohorts. Eight SNPs from six genes (PAX6, SCO2, CCDC102B, BLID, chromosome 15q14, and COL8A1) along with demographic, ophthalmic and environmental factors were analysed in two cohorts from a total of 365 highly myopic subjects and 177 control subjects. The genetic analysis showed that COL8A1 SNP rs13095226 was associated with the development of choroidal neovascularization (CNV) and also seems to play an important role in the increase of axial length. The SNP rs634990 of chromosome 15q14 also showed a significant association with MM, although this was lost after the Bonferroni correction. Additional demographic and environmental factors, namely age, sex, smoking status, and pregnancy history, were also found to be associated with MM and CNV in this population.