Rosa, P.A. (Pedro Antonio) de la

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    Associations of lockdown stringency and duration with Google searches for mental health terms during the COVID-19 pandemic: A nine-country study
    (Elsevier, 2022) Filippis, R. (Renato) de; Shoib, S. (Sheikh); Vadivel, R. (Ramyadarshni); Ransing, R. (Ramdas); Saeed, F. (Fahimeh); Nahidi, M. (Mahsa); Ullah, I. (Irfan); Turan, S. (Serkan); Jerotic, S. (Stefan); Ori, D. (Dorottya); Cowden, R.G. (Richard G.); Ramalho, R. (Rodrigo); Nagendrappa, S. (Sachin); Orsolini, L. (Laura); Rosa, P.A. (Pedro Antonio) de la; Pinto-da-Costa, M. (Mariana)
    Objectives: We examined the associations of lockdown stringency and duration with Google searches for four mental health concepts (i.e., “Anxiety,” “Depression,” “Suicide,” “Mental Health”) in nine countries (i.e., Hungary, India, Iran, Italy, Paraguay, Serbia, South Africa, Spain, Turkey) during the COVID-19 pandemic. Methods: We retrieved national-level data for each country from Google Trends and the Global Panel Database of Pandemic Policies. In our primary analysis, we used data from all countries to estimate a set of multilevel regression models examining associations of overall lockdown stringency and lockdown duration with relative search volumes for each mental health term. We repeated the models after replacing overall lockdown stringency with each of the lockdown stringency components. Results: A negative association was found between overall lockdown stringency and “Depression.” Lockdown duration and the most stringent stay-at-home requirements were negatively associated with “Anxiety.” Policies that recommended or required the cancelation of public events evidenced negative associations with “Depres- sion,” whereas associations between policies that required some or all levels of schooling to close and “Depression” were positive. Policies that recommended or required workplaces to close and those that enforced quarantines on non-citizens arriving from high-risk regions or closed borders entirely were negatively associated with “Suicide.”
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    Activities and relationships with parents as key ecological assets that encourage personal positive youth development
    (Wiley, 2021) Balaguer-Estaña, A.J. (Álvaro J.); Orejudo, S. (Santos); Osorio, A. (Alfonso); Lopez-del-Burgo, C. (Cristina); Rosa, P.A. (Pedro Antonio) de la
    Scientific literature has shown contextual factors thatpredict youth development, and family variables are themost important ones. In this study, we propose a modelthat explains the relation between family variables (re-lationship with parents and family activities) and PersonalPositive Youth Development (assessed through Life sa-tisfaction, Interiority, and Self‐control), across differentcultures. We recruited 2867 adolescents aged 12–18 years(52% female) from three countries: Spain, Mexico, andPeru. They completed an anonymous questionnaire. Werun exploratory and confirmatory factor analyses, andstructural equation modelling, testing for invariance acrosscountries and sexes. In all subsamples, positive family re-lationships were associated with adolescents' Life Sa-tisfaction. In addition, time invested on family activities wasassociated with Interiority and with Self‐control. However,some differences across cultures and sex were found in thespecific associations. Theoretical and practical implicationsare discussed regarding how to improve adolescent devel-opment through family life
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    A comparison of survival in patients with hepatocellular carcinoma and portal vein invasion treated by radioembolization or sorafenib
    (Wiley, 2016) Torre-Aláez, M.A. (Manuel Antonio) de la; Buades-Mateu, J. (Juan); Rosa, P.A. (Pedro Antonio) de la; Luè, A. (Alberto); Bustamante, F.J. (Francisco J.); Serrano, M.T. (Maria T.); Testillano, M. (Milagros); Lorente, S. (Sara); Arenas, J.I. (Juan Ignacio); Gil, C. (Cristina); Iñarrairaegui, M. (Mercedes); Sangro, B. (Bruno)
    Background & Aims: Sorafenib (SOR) is the standard of care for patients with hepatocellular carcinoma (HCC) and portal vein invasion (PVI), based on the results of phase 3 trials. However, radioembolization (RE) using yttrium-90 microspheres has been shown to achieve higher response rates and better survival in large cohorts and phase 2 trials. This study aimed to compare survival of HCC patients with PVI treated by RE or SOR. Methods: Survival among patients with HCC and PVI treated with RE or SOR in four Spanish hospitals between 2005 and 2013 was analysed retrospectively. Kaplan–Meier survival curves were plotted and baseline variables tested for prognostic value using the log-rank test. A multivariate prognostic model including variables identified in the univariate analysis and adjusted by a propensity score based on factors that may determine the probability of exposure to RE was generated using Cox regression analyses. Results: After a median follow-up of 6 months, 60 deaths had occurred: 38 and 22 in SOR and RE groups respectively. Median survival was 6.7 months (95%CI 5.2–8.1 months) for the entire cohort, and 8.8 months (95%CI 1.8–15.8) in the RE group and 5.4 months (95%CI 2.7–8.1) in the SOR group (P = 0.047). The difference in survival was still statistically significant when 13 patients in the RE group who started SOR after a median time of 8 months were censored from the analysis. Conclusions: In a cohort of patients with HCC and PVI treatment with RE was associated with a more prolonged survival compared with SOR.
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    Assessing adolescent dating violence in the yourlife project: Proposal of an instrument for spanish-speaking countries
    (MDPI, 2021) Lopez-del-Burgo, C. (Cristina); Osorio, A. (Alfonso); Rosa, P.A. (Pedro Antonio) de la; Calatrava, M. (María); Irala, J. (Jokin) de
    Background: Several instruments have been developed to assess adolescent dating violence but only few have been validated in Spanish-speaking settings. Some instruments are too long and may not be feasible to include them in a multipurpose questionnaire. We developed an instrument to be used in the YourLife project, an international project about young people lifestyles. Objective: We aimed to analyze the psychometric properties of this instrument in three Spanish-speaking countries (Chile, Ecuador, and Spain). Method: We included 1049 participants, aged 13-18 years. Exploratory and confirmatory factor analyses were conducted. Associations between dating violence and variables expected to covariate with it (substance use, school peer aggression, justification of dating violence, and relationship power imbalance), were tested. Results: Two different constructs (psychological and physical/sexual) for suffered and perpetrated violence were identified and confirmed in the three countries. The dating violence subscales had Cronbach's alpha scores higher than 0.85. The strongest associations between dating violence and variables related to it were found within the relationship power imbalance items, suggesting that these items may be useful to detect adolescent dating violence when a specific questionnaire cannot be implemented. Conclusion: This instrument seems to be adequate to assess suffered and perpetrated adolescent dating violence within a multipurpose questionnaire among schooled adolescents.