Ohlund, D. (Daniel)

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    LAMC2 regulates key transcriptional and targetable effectors to support pancreatic cancer growth
    (AACR - American Association of Cancer Research, 2023) Erice, O. (Oihane); Narayanan, S. (Shruthi); Feliu, I. (Iker); Entrialgo-Cadierno, R. (Rodrigo); Malinova, A. (Antonia); Vicentini, C. (Caterina); Guruceaga, E. (Elizabeth); Delfino, P. (Pietro); Trajkovic-Arsic, M. (Marija); Moreno, H. (Haritz); Valencia, K. (Karmele); Blanco, E. (Ester); Macaya, I. (Irati); Ohlund, D. (Daniel); Khatri, P. (Purvesh); Lecanda, F. (Fernando); Scarpa, A. (Aldo); Siveke, J. (Jens); Corbo, V. (Vincenzo); Ponz-Sarvise, M. (Mariano); Vicent, S. (Silve); Vicent, S. (Silvestre)
    The identification of pancreatic ductal adenocarcinoma (PDAC) dysregulated genes may unveil novel molecular targets entering inhibitory strategies. Laminins are emerging as potential targets in PDAC given their role as diagnostic and prognostic markers. Here, we investigated the cellular, functional, and clinical relevance of LAMC2 and its regulated network, with the ultimate goal of identifying potential therapies.