Rodriguez, M.I. (Maria Isabel)

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    Comprehensive Analysis of SWI/SNF Inactivation in Lung Adenocarcinoma Cell Models
    (2020) Patiño-Mercau, J.R. (Juan Rodrigo); Álvarez-Perez, J.C. (Juan Carlos); Romero, O.A. (Octavio A.); Medina, P.P. (Pedro P.); Coira, I.F. (Isabel F.); Cuadros, M. (Marta); Rodriguez, M.I. (Maria Isabel); Arenas, A.M. (Alberto M.); Andrades, A. (Alvaro); Montuenga-Badia, L.M. (Luis M.); Sanjuan-Hidalgo, J. (Juan); Baliñas-Gavira, C. (Carlos); Sanchez-Cespedes, M. (Montserrat); Garcia, D.J. (Daniel J.); Carretero, J. (Julian); Peinado, P. (Paola)
    Mammalian SWI/SNF (SWitch/Sucrose Non-Fermentable) complexes are ATP-dependent chromatin remodelers whose subunits have emerged among the most frequently mutated genes in cancer. Studying SWI/SNF function in cancer cell line models has unveiled vulnerabilities in SWI/SNF-mutant tumors that can lead to the discovery of new therapeutic drugs. However, choosing an appropriate cancer cell line model for SWI/SNF functional studies can be challenging because SWI/SNF subunits are frequently altered in cancer by various mechanisms, including genetic alterations and post-transcriptional mechanisms. In this work, we combined genomic, transcriptomic, and proteomic approaches to study the mutational status and the expression levels of the SWI/SNF subunits in a panel of 38 lung adenocarcinoma (LUAD) cell lines. We found that the SWI/SNF complex was mutated in more than 76% of our LUAD cell lines and there was a high variability in the expression of the different SWI/SNF subunits. These results underline the importance of the SWI/SNF complex as a tumor suppressor in LUAD and the difficulties in defining altered and unaltered cell models for the SWI/SNF complex. These findings will assist researchers in choosing the most suitable cellular models for their studies of SWI/SNF to bring all of its potential to the development of novel therapeutic applications.
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    Design and development of a low-cost wearable glove to track forces exerted by workers in car assembly lines
    (MDPI AG, 2019) Francés, L. (Leire); Rodriguez, M.I. (Maria Isabel); Sánchez-Ventura-Morer, M.I. (Maria Inés); Cazón-Martín, A.(Aitor)
    Wearables are gaining widespread use and technologies are making it possible to monitor human physical activity and behaviour as part of connected infrastructures. Many companies see wearables as an opportunity to enhance worker safety since they can monitor their workers’ activity in real life scenarios. One of the goals of this technology is to integrate existing electronic components, such as sensors or conductors, in order to create fully wearable systems. This integration is constrained not only by technical factors but also by user requirements and internal company standards. This paper considers such constraints and presents preliminary research for the design of a wearable glove as a new tool to track forces exerted by workers in car assembly lines. The objective of the glove is to measure forces and compare these to maximum forces already identified by the company. Thus, the main objectives are to: (1) integrate the components based on the requirements of the users and the context of application, and (2) provide a new tool that can be used “in situ” to track workers. This study was carried out in close collaboration with Volkswagen through a human-centred iterative design process. Thus, this paper presents the development of a wearable device glove based on a specific design methodology where both the human and technological aspects are considered.