García-Pajares, F. (Fernando)

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    Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients
    (Elsevier, 2021) Castells, L. (Lluis); Lladó, L. (Laura); Muñoz-Serrano, A. (Alejandro); García-Pajares, F. (Fernando); Otero, A. (Alejandra); González-Grande, R. (Rocío); Caballero, A. (Aránzazu); Graus, J. (Javier); Blanco-Fernández, G. (Gerardo); Fábrega, E. (Emilio); Navasa, M. (Miquel); González-Dieguez, M.L. (María Luisa); Cachero, A. (Alba); Bustamante-Schneider, J. (Javier); Rodriguez, M. (Manuel); Iñarrairaegui, M. (Mercedes); Arias-Milla, A. (Ana); Hierro, L. (Loreto); Vinaixa, C. (Carmen); Fondevila, C. (Constantino); Loinaz, C. (Carmelo); Nogueras, F. (Flor); Salcedo, M. (Magdalena); Ramírez, P. (Pablo); Colmenero, J. (Jordi); Pascual, S. (Sonia); Fernández-Yunquera, A. (Ainhoa); Álamo, J.M. (José María); Nuño, J. (Javier); Gastaca, M. (Mikel)
    In liver transplant patients, chronic immunosuppression increases the risk of acquiring COVID-19 but it could reduce disease severity. Com- plete immunosuppression with- drawal may not be justified. However, mycophenolate withdrawal or tem- porary conversion to calcineurin inhibitors or everolimus until disease resolution could be beneficial in hos- pitalised patients.
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    Epigenetic-based differentiation therapy for Acute Myeloid Leukemia
    (Springer Nature, 2024) San-Jose-Eneriz, E. (Edurne); Gimenez-Camino, N. (Naroa); Rabal, O. (Obdulia); Garate, L. (Leire); Miranda, E. (Estibaliz); Gómez-Echarte, N. (Nahia); García-Pajares, F. (Fernando); Charalampopoulou, S. (Stella); Saez, E. (Elena); Vilas-Zornoza, A. (Amaia); San-Martín-Uriz, P. (Patxi); Valcárcel-García, L.V. (Luis Vitores); Barrena, N. (Naroa); Alignani, D. (Diego); Tamariz-Amador, L.E. (Luis Esteban); Perez-Ruiz, A. (Ana); Hilscher, S. (Sebastian); Schutkowski, M. (Mike); Alfonso-Piérola, A. (Ana); Martinez-Calle, N. (Nicolas); Larrayoz, M.J. (María José); Pavia, B. (Bruno); Calasanz-Abinzano, M.J. (Maria Jose); Muñoz, J. (Javier); Isasa, M. (Marta); Martin-Subero, J.I. (Jose Ignacio); Pineda-Lucena, A. (Antonio); Oyarzabal, J. (Julen); Agirre, X. (Xabier); Prosper-Cardoso, F. (Felipe)
    Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of acute promyelocytic leukemia, their role in other acute myeloid leukemia subtypes needs to be explored. Here we identify and characterize two lysine deacetylase inhibitors, CM-444 and CM-1758, exhibiting the capacity to promote myeloid differentiation in all acute myeloid leukemia subtypes at low non-cytotoxic doses, unlike other commercial histone deacetylase inhibitors. Analyzing the acetylome after CM-444 and CM-1758 treatment reveals modulation of non-histone proteins involved in the enhancer–promoter chromatin regulatory complex, including bromodomain proteins. This acetylation is essential for enhancing the expression of key transcription factors directly involved in the differentiation therapy induced by CM-444/CM-1758 in acute myeloid leukemia. In summary, these compounds may represent effective differentiation-based therapeutic agents across acute myeloid leukemia subtypes with a potential mechanism for the treatment of acute myeloid leukemia.