Sadaba-Echarri, L.M. (Luis M.)
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- Distrofia macular anular benigna(Elsevier España, 2005) Sadaba-Echarri, L.M. (Luis M.); Corcostegui-Crespo, I. (I.); Garcia-Layana, A. (Alfredo); Salinas-Alaman, A. (Ángel)Clinical cases: Two cases of benign concentric macular dystrophy are described. In one case, ophthalmologic examination, fluorescein angiogram and visual field measurement were performed. The presence of a juxtafoveal fibrosis in the other patient, indicate that choroidal neovascularization may be associated with this type of macular dystrophy. Discussion: Benign concentric macular dystrophy is an entity with well-defined ophthalmoscopic and angiographic characteristics. Usually the prognosis is good. Rarely, choroidal neovascularization can be associated with this macular dystrophy
- Neuropatía óptica autoinmune recidivante bilateral en la infancia(Elsevier, 2006) Sadaba-Echarri, L.M. (Luis M.); Salinas-Alaman, A. (Ángel); Heras-Mulero, H. (Henar); Garcia-Gomez, P.J. (Pío J.); Belzunce, A. (Arnaldo)Clinical case: A ten year-old girl, after a Yersinia gastroenteritis, developed an optic neuritis in the left eye. She was not treated and resulted ultimately in optic atrophy on the affected side. Six months later a similar episode occurred in the contralateral eye. On this occasion corticosteroid therapy was given. During this therapy the neuritis diminished; however the patient had three relapses, so it was decided to give her immunosuppressive treatment with azathioprine and continue this indefinitely. Discussion: After considering the differential diagnoses of bilateral recurrent optical neuritis in childhood, we concluded that it was most likely to have an autoimmune basis. After considering the benefits and risks of the long-term treatment, we believe immunosuppressive therapy is most useful in controlling the disease allowing corticosteroid therapy to be reduced (Arch Soc Esp Oftalmol 2006; 81: 607-610).
- Distrofia foveomacular viteliforme del adulto(Elsevier España, 2003) Sadaba-Echarri, L.M. (Luis M.); Garcia-Layana, A. (Alfredo); Salinas-Alaman, A. (Ángel)Four cases of adult-onset foveomacular vitelliform dystrophy are shown. In two cases we were able to complete the exploration under optical coherence tomography. One of the patients developed spontaneous disappearance of the subfoveal deposit in her right eye along with an important decrease in her visual acuity. Discussion: Adult-onset foveomacular vitelliform dystrophy is characterized by yellowish round-shaped bilateral, lesions in the subfoveal area. Optical coherence tomography reveal the presence of a slightly elevated lesion wich affects the retinal pigment epithelium and the external layers of neurosensory retina
- Effect of lutein and antioxidant supplementation on VEGF expression, MMP-2 activity, and ultrastructural alterations in apolipoprotein E-deficient mouse(Hindawi Publishing Corporation, 2013) Sadaba-Echarri, L.M. (Luis M.); Rodriguez, J.A. (José Antonio); Garcia-Layana, A. (Alfredo); Salinas-Alaman, A. (Ángel); Fernandez-Robredo, P. (Patricia); Recalde, S. (Sergio)Oxidative stress is involved in the pathogenesis of several diseases such as atherosclerosis and age-related macular degeneration (AMD). ApoE-deficient mice (apoE(-/-)) are a well-established model of genetic hypercholesterolemia and develop retinal alterations similar to those found in humans with AMD. Thus supplementation with lutein or multivitamin plus lutein and glutathione complex (MV) could prevent the onset of these alterations. ApoE(-/-) mice (n = 40, 3 months old) were treated daily for 3 months with lutein (AE-LUT) or MV (two doses): AE-MV15 (15 mg/kg/day) and AE-MV50 (50 mg/kg/day) and were compared to controls with vehicle (AE-C). Wild-type mice (n = 10) were also used as control (WT-C). ApoE(-/-) mice showed higher retinal lipid peroxidation and increased VEGF expression and MMP-2 activity, associated with ultrastructural alterations such as basal laminar deposits, vacuoles, and an increase in Bruch's membrane thickness. While lutein alone partially prevented the alterations observed in apoE(-/-) mice, MV treatment substantially reduced VEGF levels and MMP-2 activity and ameliorated the retinal morphological alterations. These results suggest that oxidative stress in addition to an increased expression and activity of proangiogenic factors could participate in the onset or development of retinal alterations of apoE(-/-) mice. Moreover, these changes could be prevented by efficient antioxidant treatments.
- Hemorragia submacular traumática tratada con rt-PA y SF6(Elsevier, 2007) Sadaba-Echarri, L.M. (Luis M.); Garcia-Layana, A. (Alfredo); Salinas-Alaman, A. (Ángel); Heras-Mulero, H. (Henar); Garcia-Gomez, P.J. (Pío J.)This patient was afflicted by a traumatic submacular hemorrhage. A posterior vitrectomy was performed and intravitreal rt-PA and SF6 were administered. Four weeks later, the visual acuity had increased from 0.1 to 0.8. No complications due to the treatment with rt-PA were reported. DISCUSSION: It is known that waiting for the spontaneous blood removal in such cases results in a poor visual acuity recovery due to a toxic effect of the blood products. Both rt-PA and the SF6 are useful for the treatment of submacular hemorrhages secondary to age-related macular degeneration, and this case report has shown they are also useful to lyse traumatic blood clots, thus contributing to a better recovery of visual acuity.
- Ocular symptoms secondary to meningeal carcinomatosis in a patient with lung adenocarcinoma: a case report.(BioMed Central, 2012) Sadaba-Echarri, L.M. (Luis M.); Nova-Fernandez-Yañez, E. (Elisa) de; Sabater, A.L. (Alfonso L.)MC is a serious complication of systemic cancer patients, involving a poor prognosis. Early diagnosis is extremely important, although treatment is frequently aimed to reduce the symptoms and extend survival. Eye symptoms may be the chief complaint, so MC should be considered in any patient with vision loss or diplopia accompanied by neurologic symptoms and in the absence of an intraocular cause, especially in the context of systemic cancer.
- Aceite de silicona para el tratamiento de la maculopatía hipotónica(Elsevier España, 2005) Sadaba-Echarri, L.M. (Luis M.); Fernandez-Hortelano, A. (A.); Garcia-Layana, A. (Alfredo); Heras-Mulero, H. (Henar); Garcia-Gomez, P.J. (Pío J.)Case report: We report a case of a man who developed hypotonic maculopathy after vitreoretinal surgery for anterior proliferative vitreoretinopathy. After an injection of intravitreal triamcinolone, the ocular pressure did not increase, therefore silicone oil was injected. After this, the visual acuity increased and the choroidal and retinal folds regressed. Discussion: Hypotonic maculopathy is a frustrating problem, often resulting in poor visual acuity. There are not many effective treatments. The injection of silicone oil could be an alternative to increase the intraocular pressure and re-establish the normal anatomy of the eye, improving the visual acuity in some patients
- Termoterapia transpupilar en neovascularización subretiniana oculta secundaria a degeneración macular asociada a la edad. Primeros resultados(Elsevier España, 2002) Moreno-Montañes, J. (Javier); Sadaba-Echarri, L.M. (Luis M.); Garcia-Layana, A. (Alfredo); Sanchez-Tocino, H. (Hortensia); Juberias, J.R. (J. R.); Salinas-Alaman, A. (Ángel)To determine the efficacy of transpupillary thermotherapy (TTT) to treat choroidal neovascularization (CNV) in patients with age-related macular degeneration (ARMD). Patients and Methods: Eight patients (ten eyes) with occult CNV were treated by TTT. A 810 nm diode laser was used to perform TTT. The diode laser was delivered through a panfunduscopic contact lens. Results: Three eyes showed a visual acuity improvement and a decrease in exudation on fluorescein angiography. Four eyes remained stable. Nevertheless, lesions worsened after treatment in three cases. One of these cases suffered an overtreatment. Conclusions: TTT may be a useful therapy in some cases of CNV in patients with age-related macular degeneration. Randomized and multicentric studies are necessary to stablish precise indications of this therapy
- Azoor. Tras una lesión por latigazo cervical(Servicio de Publicaciones de la Universidad de Navarra, 2001) Sadaba-Echarri, L.M. (Luis M.); Sainz-Gomez, C. (C.); Garcia-Layana, A. (Alfredo); Maldonado, M.J. (Miguel J.); Moreno, J. (J.)Purpose/Method: To present a case of a 30 years old woman that suffered a car accident one year ago, diagnosed of cervical sprain. One month after the accident, the patient saw a black stein in the outer side of the visuald field on the left eye.Results/Conclusions: Brain CAT, evocated visual potencials, color test and MRI were within of the normality. Acording with the ophtalmic examination, visual field test and OCT (optical coherence tomography), the diagnosis was acute zonal occult outer retinopathy (AZOOR).
- Medición de presión intraocular con el tonómetro Proview®(Elsevier España, 2005) Moreno-Montañes, J. (Javier); Sadaba-Echarri, L.M. (Luis M.); Heras-Mulero, H. (Henar)Purpose: To evaluate a new ocular tonometer (Proview®) which functions by visualizing a phosphene after putting pressure on the upper eyelid. To ascertain its accuracy and reproducibility with respect to the Goldmann tonometer (GT). Methods: A study on both eyes of 110 non-selected patients was performed. One measurement with GT and three subsequent measurements with Proview® were taken by the same investigator. The number of failed attempts to visualize the phosphene was recorded. We evaluated each eye separately to observe the possible learning effect. Results: The intraocular pressure (IOP) mean with Proview® is 5 mm Hg higher than the GT (p<0.001). The coefficient of correlation between both instruments is low (R = 0.67; R2=0.45) in the right eye (RE). The difference between maximum and minimum values of the 3 measurements taken with the Proview® was 3.21 (SD: 1.73) mm Hg in RE. The failed attempts to see the phosphene were 5.14 (SD: 2.39) in RE and 4.93 (SD: 2.78) in left eye (p>0.05). Conclusions: The Proview® tonometer showed low accuracy and reproducibility in comparison with the GT. This tonometer requires a long learning process before phosphene visualization. The results demonstrated that this tonometer is not clinically useful, except in patients with serious corneal diseases which make measurement with GT very difficult