Handjiev, S. (Svetoslav)
- Publications
- item.page.relationships.isContributorAdvisorOfPublication
- item.page.relationships.isContributorOfPublication
Search Results
Now showing 1 - 2 of 2
- PREVIEW study-influence of a behavior modification intervention (PREMIT) in over 2300 people with pre-diabetes: intention, self-efficacy and outcome expectancies during the early phase of a lifestyle intervention(Taylor and Francis Group, 2018) Martinez, J.A. (José Alfredo); Handjiev, S. (Svetoslav); Sando-Pedersen, F. (Finn); Schlicht, W. (Wolfgang); Brand-Miller, J. (Jennie); Pietiläinen, K.H. (Kirsi H.); Raben, A. (Anne); Berendsen, A.A.M. (Agnes A. M.); Silvestre, M.P. (Marta P.); Navas-Carretero, S. (Santiago); Taylor, M. (Moira); Adam, T.C. (Tanja C.); Huttunen-Lenz, M. (Maija); Drummen, M. (Mathijs); Fogelholm, M. (Mikael); Poppitt, S.D. (Sally D.); Hansen, S. (Sylvia); Meinert-Larsen, T. (Thomas); MacDonald, I. (Ian); Christensen, P. (Pia)Purpose: Onset of type 2 diabetes (T2D) is often gradual and preceded by impaired glucose homeostasis. Lifestyle interventions including weight loss and physical activity may reduce the risk of developing T2D, but adherence to a lifestyle change is challenging. As part of an international T2D prevention trial (PREVIEW), a behavior change intervention supported participants in achieving a healthier diet and physically active lifestyle. Here, our aim was to explore the influence of this behavioral program (PREMIT) on social-cognitive variables during an 8-week weight loss phase. Methods: PREVIEW consisted of an initial weight loss, Phase I, followed by a weightmaintenance, Phase II, for those achieving the 8-week weight loss target of ≥ 8% from initial bodyweight. Overweight and obese (BMI ≥25 kg/m2) individuals aged 25 to 70 years with confirmed pre-diabetes were enrolled. Uni- and multivariate statistical methods were deployed to explore differences in intentions, self-efficacy, and outcome expectancies between those who achieved the target weight loss (“achievers”) and those who did not (“non-achievers”). Results: At the beginning of Phase I, no significant differences in intentions, self-efficacy and outcome expectancies between “achievers” (1,857) and “non-achievers” (163) were found. “Non-achievers” tended to be younger, live with child/ren, and attended the PREMIT sessions less frequently. At the end of Phase I, “achievers” reported higher intentions (healthy eating χ2 (1)=2.57; P <0.008, exercising χ2 (1)=0.66; P <0.008), self-efficacy (F(2; 1970)=10.27, P <0.005), and were more positive about the expected outcomes (F(4; 1968)=11.22, P <0.005). Conclusion: Although statistically significant, effect sizes observed between the two groups were small. Behavior change, however, is multi-determined. Over a period of time, even small differences may make a cumulative effect. Being successful in behavior change requires that the “new” behavior is implemented time after time until it becomes a habit. Therefore, having even slightly higher self-efficacy, positive outcome expectancies and intentions may over time result in considerably improved chances to achieve long-term lifestyle changes.
- Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW)(Wiley, 2018) Martinez, J.A. (José Alfredo); Handjiev, S. (Svetoslav); Sando-Pedersen, F. (Finn); Brodie, S. (Shannon); Ritz, C. (Christian); Pastor-Sanz, L. (Laura); Brand-Miller, J. (Jennie); Westerterp-Plantenga, M. (Margriet); Pietiläinen, K.H. (Kirsi H.); Raben, A. (Anne); Handjieva-Darlenska, T. (Teodora); Silvestre, M.P. (Marta P.); Astrup, A. (Arne); Navas-Carretero, S. (Santiago); Taylor, M. (Moira); Sundvall, J. (Jouko); Huttunen-Lenz, M. (Maija); Drummen, M. (Mathijs); Fogelholm, M. (Mikael); Poppitt, S.D. (Sally D.); Hansen, S. (Sylvia); Meinert-Larsen, T. (Thomas); MacDonald, I. (Ian); Christensen, P. (Pia)Aims: The PREVIEW lifestyle intervention study (ClinicalTrials.gov Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type-2 diabetes. We hypothesized that the initial, fixed low-energy diet (LED) would induce different metabolic outcomes in men vs women. Materials and methods: All participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI ≥ 25 kg/m2 ) individuals with pre-diabetes according to ADA-criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat-free mass (FFM) and metabolic syndrome Z-score. Results: In total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow-up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA-IR decreased by 1.50 ± 0.15 in men and by 1.35 ± 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z-score, C-peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo-glycaemia. Conclusions: An 8-week LED induced different effects in women than in men. These findings are clinically important and suggest gender-specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.