Solmi, M. (Marco)

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Now showing 1 - 3 of 3
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    Associations between mental and physical conditions in children and adolescents: An umbrella review
    (2022) Eudave-Ramos, L.H. (Luis Humberto); Carvalho, A.F. (André F.); Ciaurriz-Larraz, A. (Amaia); Correll, C. (Christoph); Cortese, S. (Samuele); Dragioti, E. (Elena); Arrondo, G. (Gonzalo); Solmi, M. (Marco); Fusar-Poli, P. (Paolo); Magallon-Recalde, S. (Sara); Cipriani, A. (Andrea); Ruiz-Goikoetxea, M. (Maite); Larsson, H. (Henrik)
    We mapped the evidence on the type and strength of associations between a broad range of mental and physical conditions in children and adolescents, by carrying out an umbrella review, i.e., a quantitative synthesis of previous systematic reviews and meta-analyses. We also assessed to which extent the links between mental and physical conditions vary across disorders or, by contrast, are transdiagnostic. Based on a pre-established protocol, we retained 45 systematic reviews/meta-analyses, encompassing around 12.5 million of participants. In analyses limited to the most rigorous estimates, we found evidence for the following associations: ADHD-asthma, ADHD-obesity, and depression-asthma. A transdiagnostic association was confirmed between asthma and anxiety/ASD/depression/bipolar disorder, between obesity and ADHD/ASD/depression, and between dermatitis and ASD/ADHD. We conclude that obesity and allergic conditions are likely to be associated with mental disorders in children and adolescents. Our results can help clinicians explore potential links between mental and physical conditions in children/adolescent and provide a road map for future studies aimed at shading light on the underlying factors.
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    Beyond the p factor: Is there a d factor?
    (2021) Correll, C. (Christoph); Cortese, S. (Samuele); Arrondo, G. (Gonzalo); Solmi, M. (Marco)
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    Association between autism spectrum disorder and diabetes: systematic review and meta-analysis
    (Elsevier, 2022) Shin, J.I. (Jae Il); Gabellone, A. (Alessandra); Cortese, S. (Samuele); Iturmendi-Sabater, I. (Iciar); Arrondo, G. (Gonzalo); Solmi, M. (Marco); Chica-Duarte, D. (Diego) de la; Piqué, I.M. (Isabella M.); Margari, L. (Lucia); Marzulli, L. (Lucia)
    There is mixed evidence on the link between autism spectrum disorder (ASD) and diabetes. We conducted the first systematic review/meta-analysis on their association. Based on a pre-registered protocol (PROSPERO: CRD42021261114), we searched Pubmed, Ovid, and Web of Science databases up to 6 December 2021, with no language/type of document restrictions. We assessed study quality using the Newcastle-Ottawa Scale (NOS). We included 24 studies (total: 3427,773 individuals; 237,529 with ASD and 92,832 with diabetes) in the systematic review and 20 in the meta-analysis (mean stars number on the NOS: 5.89/10). There was a significant association, albeit characterized by significant heterogeneity, when pooling unadjusted OR (1.535, 95% CI = 1.109-2.126), which remained significant when restricting the analysis to children and type 2 diabetes, but became non-significant when considering adjusted ORs (OR: 1.528, 95% CI = 0.954-2.448). No significant prospective association was found (n = 2) on diabetes predicting ASD (HR: 1.232, 0.826-11.837). Therefore, the association between ASD and diabetes is likely confounded by demographic and clinical factors that should be systematically investigated in future studies.