Bernal-López, M.R. (María Rosa)

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    Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk
    (MDPI AG, 2019) Babio, N. (Nancy); Portoles, O. (Olga); Martinez-Gonzalez, M.A. (Miguel Ángel); Eguaras, S. (Sonia); Sorto-Sánchez, C. (Carolina); Fiol, M. (Miquel); Fito, M. (Montserrat); Tojal-Sierra, L. (Lucas); Martín-Sánchez, V. (Vicente); Konieczna, J. (Jadwiga); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); Vioque, J. (Jesús); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Toledo, E. (Estefanía); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Barrubés, L. (Laura); Orozco-Beltrán, D. (Domingo); Lapetra, J. (José); Zomeño, M.D. (María Dolores); Matía-Martín, P. (Pilar); Bouzas, C. (Cristina); Schröder, H. (Helmut); López-Miranda, J. (José); Coltell, O. (Oscar); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Bibiloni, M.M. (Maria del Mar); Perez-Vega, K.A. (Karla Alejandra); Julibert, A. (Alicia); Casas, R. (Rosa); Carabaño-Moral, R. (Rosa); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); García-Molina, L. (Laura); Estruch, R. (Ramón); Gaforio, J.J. (José Juan); Martinez, A. (Alfredo); Ugarriza, L. (Lucía); Santos-Lozano, J.M. (José M.); Sanchez-Villegas, A. (Almudena); Serra-Majem, L. (Luis); Corella, D. (Dolores); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Torres-Collado, L. (Laura); Bernal-López, M.R. (María Rosa); Galera, A. (Ana); PREDIMED-PLUS Investigators
    Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55-75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3-1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.
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    Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study
    (MDPI, 2020) Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Oncina-Canovas, A. (Alejandro); Garcia-Rios, A. (Antonio); Tojal-Sierra, L. (Lucas); Gimenez-Alba, I.M. (Ignacio Manuel); Martín-Sánchez, V. (Vicente); Martín, M. (Marian); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); García-Gavilán, J.F. (Jesús F.); Vioque, J. (Jesús); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Lapetra, J. (José); Zomeño, M.D. (María Dolores); Matía-Martín, P. (Pilar); Bouzas, C. (Cristina); Angullo-Martínez, E. (Escarlata); Bueno-Cavanillas, A. (Aurora); Casañas-Quintana, T. (Tamara); Basora, J. (Josep); Belló-Mora, M.C. (María C.); Castro-Barquero, S. (Sara); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Notario-Barandiaran, L. (Leyre); Fernández-Lázaro, C.I. (César I.); Bibiloni, M.M. (Maria del Mar); Julibert, A. (Alicia); Goday, A. (Albert); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Saiz, C. (Carmen); Gaforio, J.J. (José Juan); Santos-Lozano, J.M. (José M.); Pérez-Lopez, J. (Jessica); Serra-Majem, L. (Luis); Corella, D. (Dolores); Basterra-Gortari, F.J. (Francisco Javier); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Muñoz, J. (Julia); Salas-Salvado, J. (Jordi); Morey, M. (Marga); Bernal-López, M.R. (María Rosa); Galera, A. (Ana); Sayon-Orea, C. (Carmen)
    Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1: <10%, n = 1495; Q2: 10–15%, n = 1804; Q3: <15–20%, n = 1470; Q4: ≥20%, n = 1589).
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    Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-plus trial
    (Springer, 2022) Buil, P. (Pilar); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Oncina-Canovas, A. (Alejandro); Martinez-Gonzalez, M.A. (Miguel Ángel); Garcia-Rios, A. (Antonio); Fito, M. (Montserrat); Tojal-Sierra, L. (Lucas); Martín-Sánchez, V. (Vicente); Pérez-Farinós, N. (Napoleón); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); García-Gavilán, J.F. (Jesús F.); Vioque, J. (Jesús); Moñino, M. (Manuel); Ortega-Azorin, C. (Carolina); Zulet, M.A. (María Ángeles); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Toledo, E. (Estefanía); Romaguera, D. (Dora); Muralidharan, J. (Jananee); San-Julián-Aranguren, B. (Beatriz); Vázquez, C. (Clotilde); Sacanella, E. (Emilio); Lapetra, J. (José); Matía-Martín, P. (Pilar); Bueno-Cavanillas, A. (Aurora); Schröder, H. (Helmut); Delgado-Rodriguez, M. (Miguel); López-Miranda, J. (José); Goicolea-Güemez, L. (Leire); Razquin, C. (Cristina); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Fernández-Lázaro, C.I. (César I.); Goday, A. (Albert); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Vazquez-Ruiz, Z. (Zenaida); Santos-Lozano, J.M. (José M.); Serra-Majem, L. (Luis); Corella, D. (Dolores); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Sorli, J.V. (Jose V.); Bernal-López, M.R. (María Rosa)
    Purpose Long-term nutrition trials may fail to respond to their original hypotheses if participants do not comply with the intended dietary intervention. We aimed to identify baseline factors associated with successful dietary changes towards an energy-reduced Mediterranean diet (MedDiet) in the PREDIMED-Plus randomized trial. Methods Longitudinal analysis of 2985 participants (Spanish overweight/obese older adults with metabolic syndrome) randomized to the active intervention arm of the PREDIMED-Plus trial. Dietary changes were assessed with a 17-item energyreduced MedDiet questionnaire after 6 and 12 months of follow-up. Successful compliance was defned as dietary changes from baseline of≥5 points for participants with baseline scores<13 points or any increase if baseline score was≥13 points. We conducted crude and adjusted multivariable logistic regression models to identify baseline factors related to compliance. Results Consistent factors independently associated with successful dietary change at both 6 and 12 months were high baseline perceived self-efcacy in modifying diet (OR6-month: 1.51, 95% CI 1.25–1.83; OR12-month: 1.66, 95% CI 1.37–2.01), higher baseline fber intake (OR6-month: 1.62, 95% CI 1.07–2.46; OR12-month: 1.62, 95% CI 1.07–2.45), having>3 chronic conditions (OR6-month: 0.65, 95% CI 0.53–0.79; OR12-month: 0.76, 95% CI 0.62–0.93), and sufering depression (OR6-month: 0.80, 95% CI 0.64–0.99; OR12-month: 0.71, 95% CI 0.57–0.88). Conclusion Our results suggested that recruitment of individuals with high perceived self-efcacy to dietary change, and those who initially follow diets relatively richer in fber may lead to greater changes in nutritional recommendations. Participants with multiple chronic conditions, specifcally depression, should receive specifc tailored interventions.
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    The effect of physical activity and high body mass index on health-related quality of life in individuals with metabolic syndrome
    (MDPI AG, 2020) Babio, N. (Nancy); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Martinez-Gonzalez, M.A. (Miguel Ángel); Sorto-Sánchez, C. (Carolina); Galilea-Zabalza, I. (Iñigo); Garcia-Rios, A. (Antonio); Marcos-Delgado, A. (Alba); Gimenez-Alba, I.M. (Ignacio Manuel); Palau-Galindo, A. (Antoni); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); Vaquero-Luna, J. (Jessica); Vioque, J. (Jesús); Ortega-Azorin, C. (Carolina); Zulet, M.A. (María Ángeles); Becerra-Tomas, N. (Nerea); Pastor-Morel, A. (Ana); Tur, J.A. (Josep A.); Toledo, E. (Estefanía); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Fernández-Villa, T. (Tania); Paz, J.A. (José Antonio) de; Muñoz-Martínez, J. (Júlia); Lapetra, J. (José); Zomeño, M.D. (María Dolores); Matía-Martín, P. (Pilar); Delgado-Rodriguez, M. (Miguel); López-Miranda, J. (José); Galmes-Panades, A.M. (Aina M.); Ros, E. (Emilio); Perez-Vega, K.A. (Karla Alejandra); Casas, R. (Rosa); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); García-Molina, L. (Laura); Estruch, R. (Ramón); Vazquez-Ruiz, Z. (Zenaida); Santos-Lozano, J.M. (José M.); Pérez-Lopez, J. (Jessica); Serra-Majem, L. (Luis); Corella, D. (Dolores); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Martin, V. (Vicente); Bernal-López, M.R. (María Rosa)
    The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironí del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.