Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
dadun.citation.endingPage | 1743 | es_ES |
dadun.citation.number | 2018 | es_ES |
dadun.citation.publicationName | Clinical nutrition | es_ES |
dadun.citation.startingPage | 1736 | es_ES |
dadun.citation.volume | 37 | es_ES |
dc.contributor.author | Babio, N. (Nancy) | |
dc.contributor.author | Martinez, J.A. (José Alfredo) | |
dc.contributor.author | Martinez-Gonzalez, M.A. (Miguel Ángel) | |
dc.contributor.author | Fito, M. (Montserrat) | |
dc.contributor.author | Zulet, M.A. (María Ángeles) | |
dc.contributor.author | Shivappa, N. (Nitin) | |
dc.contributor.author | Tur, J.A. (Josep A.) | |
dc.contributor.author | Gomez-Gracia, E. (Enrique) | |
dc.contributor.author | Ruiz-Canela, M. (Miguel) | |
dc.contributor.author | Portillo, M.P. (María P.) | |
dc.contributor.author | Wärnberg, J. (Julia) | |
dc.contributor.author | Estruch, R. (Ramón) | |
dc.contributor.author | Corella, D. (Dolores) | |
dc.contributor.author | Abete, I. (Itziar) | |
dc.contributor.author | Pinto, X. (Xavier) | |
dc.contributor.author | Cantero-González, I. (Irene) | |
dc.contributor.author | Salas-Salvado, J. (Jordi) | |
dc.contributor.author | Hebert, J.R. (James R.) | |
dc.contributor.author | Aros, F. (Fernando) | |
dc.date.accessioned | 2024-01-10T15:15:08Z | |
dc.date.available | 2024-01-10T15:15:08Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvencion con DIeta MEDiterr anea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-a and C-reactive protein). Furthermore, a validated 137-item food-frequencyquestionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative antiinflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. | es_ES |
dc.description.sponsorship | The PREDIMED trial was supported by the Instituto de Salud Carlos III (ISCIII): RETIC G03/140 (to R. E.), CIBERobn and RETIC RD 06/0045 (to M. A. M.-G.). ICG holds a grant from the Centre for Nutrition Research of the University of Navarra. | es_ES |
dc.identifier.citation | Cantero-González, I. (Irene); Abete, I. (Itziar); Babio, N. (Nancy); et al. "Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial". Clinical nutrition. 37 (2018), 2018, 1736 - 1743 | es |
dc.identifier.doi | 10.1016/j.clnu.2017.06.027 | |
dc.identifier.issn | 0261-5614 | |
dc.identifier.pmid | 28734553 | |
dc.identifier.uri | https://hdl.handle.net/10171/68265 | |
dc.language.iso | spa | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/340918/EU | es_ES |
dc.relation.center | Facultad de Farmacia y Nutrición | |
dc.relation.department | Departamento de Ciencias de la Alimentación, Fisiología y Toxicología | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Liver | es_ES |
dc.subject | Diet | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | NAFLD | es_ES |
dc.subject | Obesity | es_ES |
dc.title | Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dspace.entity.type | Publication | es |
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