CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro

dc.contributor.authorCiveira, M.P. (María Pilar)
dc.contributor.authorBorras-Cuesta, F. (Francisco)
dc.contributor.authorSarin, P.S. (Prem S.)
dc.contributor.authorPrieto, J. (Jesús)
dc.contributor.authorPrieto, I. (Isidro)
dc.contributor.authorSarobe, P. (Pablo)
dc.contributor.authorGolvano, J.J. (José Javier)
dc.contributor.authorGullon, A. (Arturo)
dc.contributor.authorLasarte, J.J. (Juan José)
dc.date.accessioned2012-04-13T15:20:28Z
dc.date.available2012-04-13T15:20:28Z
dc.date.issued1994
dc.description.abstractPhenylalanine-containing peptides from CD4 were synthesized based on chemical similarity with active CD4(81-92)-benzylated peptides. The synthetic peptide FYIFFVEDQKEEDD blocked the binding of gp120 to CD4 and inhibited 50% human immunodeficiency virus (HIV)-induced syncytia formation at a concentration (IC50) of approximately 40-50 microM and HIV p17 expression with an IC50 of approximately 67 microM. The peptide is not toxic to cells in vitro. Moreover, acute toxicity studies carried out in Swiss mice showed the peptide to be nontoxic at a dose of 2,000 mg/kg. This phenylalanine-substituted CD4 peptide may prove to be useful in the treatment of AIDS.es_ES
dc.identifier.citationLasarte JJ, Sarobe P, Golvano J, Prieto I, Civeira MP, Gullon A, et al. CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro. J Acquir Immune Defic Syndr 1994 Feb;7(2):129-134.es_ES
dc.identifier.issn1944-7884
dc.identifier.urihttps://hdl.handle.net/10171/21653
dc.language.isoenges_ES
dc.publisherLippincott, Williams & Wilkinses_ES
dc.relation.centerClínica Universidad de Navarra
dc.relation.centerCIMA (Centro de Investigación Médica Aplicada)
dc.relation.departmentInmunología e Inmunoterapia - Inmunología experimental
dc.relation.departmentInmunología e Inmunoterapia - Inmunología hepatitis virales
dc.relation.departmentMedicina Interna
dc.relation.publisherversionhttp://bit.ly/HeCxzFes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHIV-1/drug effectses_ES
dc.subjectPeptides/pharmacologyes_ES
dc.subjectPhenylalanine/chemistryes_ES
dc.subjectViral Proteinses_ES
dc.titleCD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitroes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES
dspace.entity.typePublicationes
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