Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Casares, N. (Noelia) | - |
dc.creator | Rudilla, F. (Francesc) | - |
dc.creator | Arribillaga, L. (Laura) | - |
dc.creator | Llopiz, D. (Diana) | - |
dc.creator | Riezu-Boj, J.I. (José Ignacio) | - |
dc.creator | Lozano-Moreda, T. (Teresa) | - |
dc.creator | Lopez-Sagaseta, J. (Jacinto) | - |
dc.creator | Guembe, L. (L.) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.date.accessioned | 2010-11-30T09:37:07Z | - |
dc.date.available | 2010-11-30T09:37:07Z | - |
dc.date.issued | 2010-11-25 | - |
dc.identifier.citation | Casares N, Rudilla F, Arribillaga L, Llopiz D, Riezu-Boj JI, Lozano T, et al. A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice. J Immunol 2010 Nov 1;185(9):5150-5159. | es_ES |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10171/14321 | - |
dc.description.abstract | Immunosuppressive activity of regulatory T cells (Treg) may contribute to the progression of cancer or infectious diseases by preventing the induction of specific immune responses. Using a phage-displayed random peptide library, we identified a 15-mer synthetic peptide, P60, able to bind to forkhead/winged helix transcription factor 3 (FOXP3), a factor required for development and function of Treg. P60 enters the cells, inhibits FOXP3 nuclear translocation, and reduces its ability to suppress the transcription factors NF-κB and NFAT. In vitro, P60 inhibited murine and human-derived Treg and improved effector T cell stimulation. P60 administration to newborn mice induced a lymphoproliferative autoimmune syndrome resembling the reported pathology in scurfy mice lacking functional Foxp3. However, P60 did not cause toxic effects in adult mice and, when given to BALB/c mice immunized with the cytotoxic T cell epitope AH1 from CT26 tumor cells, it induced protection against tumor implantation. Similarly, P60 improved the antiviral efficacy of a recombinant adenovirus expressing NS3 protein from hepatitis C virus. Functional inhibition of Treg by the FOXP3-inhibitory peptide P60 constitutes a strategy to enhance antitumor and antiviral immunotherapies. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association of Immunologists | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Peptide | es_ES |
dc.subject | Inhibitor | es_ES |
dc.subject | FOXP3 | es_ES |
dc.subject | T Cell Activity | es_ES |
dc.subject | Improves | es_ES |
dc.subject | Vaccine | es_ES |
dc.subject | Efficacy in mice | es_ES |
dc.title | A peptide inhibitor of FOXP3 impairs regulatory T cell Activity and improves vaccine efficacy in mice | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.4049/jimmunol.1001114 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.