Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Mazo, M. (Manuel) | - |
dc.creator | Planat-Benard, V. (Valérie) | - |
dc.creator | Abizanda-Sarasa, G. (Gloria) | - |
dc.creator | Pelacho, B. (Beatriz) | - |
dc.creator | Leobon, B. (Bertrand) | - |
dc.creator | Gavira, J.J. (Juan José) | - |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | - |
dc.creator | Cemborain, A. (A.) | - |
dc.creator | Penicaud, L. (Luc) | - |
dc.creator | Laharrague, P. (Patrick) | - |
dc.creator | Joffre, C. (Carine) | - |
dc.creator | Boisson, M. (M.) | - |
dc.creator | Ecay, M. (Margarita) | - |
dc.creator | Collantes, M. (María) | - |
dc.creator | Barba, J. (Joaquín) | - |
dc.creator | Casteilla, L. (L.) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.date.accessioned | 2011-02-24T10:36:13Z | - |
dc.date.available | 2011-02-24T10:36:13Z | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | Mazo M, Planat-Benard V, Abizanda G, Pelacho B, Leobon B, Gavira JJ, et al. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 2008 May;10(5):454-462. | es_ES |
dc.identifier.issn | 1388-9842 | - |
dc.identifier.uri | https://hdl.handle.net/10171/16659 | - |
dc.description.abstract | Aims: To determine the effect of transplantation of undifferentiated and cardiac pre-differentiated adipose stem cells compared with bone marrow mononuclear cells (BM-MNC) in a chronic model of myocardial infarction. Methods: Ninety-five Sprague–Dawley rats underwent left coronary artery ligation and after 1month received by direct intramyocardial injection either adipose derived stem cells (ADSC), cardiomyogenic cells (AD-CMG) or BM-MNC from enhanced-Green Fluorescent Protein (eGFP) mice. The control group was treated with culture medium. Heart function was assessed by echocardiography and 18F-FDG microPET. Cell engraftment, differentiation, angiogenesis and fibrosis in the scar tissue were also evaluated by (immuno)histochemistry and immunofluorescence. Results: One month after cell transplantation, ADSC induced a significant improvement in heart function (LVEF 46.3±9.6% versus 27.7±8% pre-transplant) and tissue viability (64.78±7.2% versus 55.89±6.3% pre-transplant). An increase in the degree of angiogenesis and a decrease in fibrosis were also detected. Although transplantation of AD-CMG or BM-MNC also had a positive, albeit smaller, effect on angiogenesis and fibrosis in the infarcted hearts, this benefit did not translate into a significant improvement in heart function or tissue viability. Conclusion: These results indicate that transplantation of adipose derived cells in chronic infarct provides a superior benefit to cardiac pre-differentiated ADSC and BM-MNC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Cell therapy | es_ES |
dc.subject | Chronic ischaemic heart failure | es_ES |
dc.subject | Stem cells | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.title | Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/j.ejheart.2008.03.017 | es_ES |
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