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dc.creatorMazo, M. (Manuel)-
dc.creatorPlanat-Benard, V. (Valérie)-
dc.creatorAbizanda-Sarasa, G. (Gloria)-
dc.creatorPelacho, B. (Beatriz)-
dc.creatorLeobon, B. (Bertrand)-
dc.creatorGavira, J.J. (Juan José)-
dc.creatorPeñuelas-Sanchez, I. (Ivan)-
dc.creatorCemborain, A. (A.)-
dc.creatorPenicaud, L. (Luc)-
dc.creatorLaharrague, P. (Patrick)-
dc.creatorJoffre, C. (Carine)-
dc.creatorBoisson, M. (M.)-
dc.creatorEcay, M. (Margarita)-
dc.creatorCollantes, M. (María)-
dc.creatorBarba, J. (Joaquín)-
dc.creatorCasteilla, L. (L.)-
dc.creatorProsper-Cardoso, F. (Felipe)-
dc.date.accessioned2011-02-24T10:36:13Z-
dc.date.available2011-02-24T10:36:13Z-
dc.date.issued2008-05-
dc.identifier.citationMazo M, Planat-Benard V, Abizanda G, Pelacho B, Leobon B, Gavira JJ, et al. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 2008 May;10(5):454-462.es_ES
dc.identifier.issn1388-9842-
dc.identifier.urihttps://hdl.handle.net/10171/16659-
dc.description.abstractAims: To determine the effect of transplantation of undifferentiated and cardiac pre-differentiated adipose stem cells compared with bone marrow mononuclear cells (BM-MNC) in a chronic model of myocardial infarction. Methods: Ninety-five Sprague–Dawley rats underwent left coronary artery ligation and after 1month received by direct intramyocardial injection either adipose derived stem cells (ADSC), cardiomyogenic cells (AD-CMG) or BM-MNC from enhanced-Green Fluorescent Protein (eGFP) mice. The control group was treated with culture medium. Heart function was assessed by echocardiography and 18F-FDG microPET. Cell engraftment, differentiation, angiogenesis and fibrosis in the scar tissue were also evaluated by (immuno)histochemistry and immunofluorescence. Results: One month after cell transplantation, ADSC induced a significant improvement in heart function (LVEF 46.3±9.6% versus 27.7±8% pre-transplant) and tissue viability (64.78±7.2% versus 55.89±6.3% pre-transplant). An increase in the degree of angiogenesis and a decrease in fibrosis were also detected. Although transplantation of AD-CMG or BM-MNC also had a positive, albeit smaller, effect on angiogenesis and fibrosis in the infarcted hearts, this benefit did not translate into a significant improvement in heart function or tissue viability. Conclusion: These results indicate that transplantation of adipose derived cells in chronic infarct provides a superior benefit to cardiac pre-differentiated ADSC and BM-MNC.es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectCell therapyes_ES
dc.subjectChronic ischaemic heart failurees_ES
dc.subjectStem cellses_ES
dc.subjectAngiogenesises_ES
dc.titleTransplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarctiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejheart.2008.03.017es_ES

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