Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation

Quincoces, G. (Gemma); Peñuelas-Sanchez, I. (Ivan); Valero, M. (Marta); Serra, P. (Patricia); Collantes, M. (María); Marti-Climent, J.M. (Josep María); Arbizu, J. (Javier); Garcia-Velloso, M. J. (María José); Richter, J.A. (José Ángel)

Keywords:

Simultaneous synthesis
[11C]methylation
[11C]methionine
[11C]choline

Issue Date:

15-Feb-2006

Publisher:

Elsevier

ISSN:

0969-8043

Citation:

Quincoces, G. (Gemma); Peñuelas, I. (Iván); Valero, M. (Marta); et al. "Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation". En . , 2006-02-15,

Abstract

We herein describe a simple setup for the automated simultaneous synthesis of l-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation . The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.

URI:

https://hdl.handle.net/10171/16834

DOI:

http://dx.doi.org/10.1016/j.apradiso.2006.03.001

Appears in Collections:

DA - Ciencias - HAP - Artículos de revista
DA - CIMA - MicroPET - Artículos de Revista

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