Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Roman-Gomez, J. (José) | |
| dc.creator | Jimenez-Velasco, A. (A.) | |
| dc.creator | Aguirre-Ena, X. (Xabier) | |
| dc.creator | Castillejo, J.A. (J.A.) | |
| dc.creator | Navarro, G. (Germán) | |
| dc.creator | San-Jose-Eneriz, E. (Edurne) | |
| dc.creator | Garate, L. (Leire) | |
| dc.creator | Cordeu, L. (Lucía) | |
| dc.creator | Cervantes, F. (F.) | |
| dc.creator | Prosper-Cardoso, F. (Felipe) | |
| dc.creator | Heiniger, A. (A.) | |
| dc.creator | Torres, A. (Antonio) | |
| dc.date.accessioned | 2011-04-13T14:01:18Z | - |
| dc.date.available | 2011-04-13T14:01:18Z | - |
| dc.date.issued | 2007 | - |
| dc.identifier.citation | Román-Gómez, J., Jiménez-Velasco, A., Agirre, X., Castillejo, J. A. et al. Leukemia Research 2007; 31 (11): 1521-1528 | es_ES |
| dc.identifier.issn | 0145-2126 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/17700 | - |
| dc.description.abstract | Repetitive elements are heavily methylated in normal tissues, but hypomethylated in malignant tissues, driving the global genomic hypomethylation found in cancer. This hypomethylation results in chromosomal instability, a well-characterized feature of the advanced phases of chronic myeloid leukemia (CML). We investigated methylation changes of DNA repetitive elements (LINE1, Alu, Satellite-alpha and Satellite-2) during the progression of CML from chronic phase (CP) to blast crisis (BC). CP-CML samples were significantly more hypomethylated for all repetitive sequences compared with normal samples. Furthermore, a more profound level of hypomethylation was observed among BC samples compared with CP samples. Our data suggest that repetitive DNA hypomethylation are closely associated with CML progression. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.rights | info:eu-repo/semantics/closedAccess | - |
| dc.subject | LINE1 | es_ES |
| dc.subject | Alu | es_ES |
| dc.subject | Satellite-alpha | es_ES |
| dc.subject | Satellite-2 | es_ES |
| dc.subject | Hypomethylation | es_ES |
| dc.subject | CML | es_ES |
| dc.title | Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/journal/01452126 | es_ES |
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