Full metadata record
DC Field | Value | Language |
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dc.creator | San-Jose, G. (Gorka) | |
dc.creator | Fortuño, A. (Ana) | |
dc.creator | Moreno, M.U. (María Ujué) | |
dc.creator | Robador, P.A. (Pablo A.) | |
dc.creator | Bidegain, J. (J.) | |
dc.creator | Varo-Cenarruzabeitia, M.N. (Miren Nerea) | |
dc.creator | Beloqui, O. (Óscar) | |
dc.creator | Diez-Martinez, J. (Javier) | |
dc.creator | Zalba, G. (Guillermo) | |
dc.date.accessioned | 2011-05-19T08:39:17Z | - |
dc.date.available | 2011-05-19T08:39:17Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | San Jose G, Fortuño A, Moreno MU, Robador PA, Bidegain J, Varo N, et al. The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension. Clin Sci (Lond) 2009 Feb;116(3):233-240. | es_ES |
dc.identifier.issn | 1470-8736 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18012 | - |
dc.description.abstract | The objective of the present study was to analyse the influence of the ACE (angiotensin-converting enzyme) gene I/D (insertion/deletion) polymorphism on NADPH oxidase-dependent O(2)(*-) (superoxide radical) production, and to investigate the clinical implication of this association in hypertensive subjects. A case-control study was performed in a random sample of the general population composed of 189 normotensive subjects and 223 hypertensive subjects. The ACE polymorphism was determined by PCR. NADPH oxidase-dependent O(2)(*-) production was quantified in phagocytic cells by chemiluminescence. MMP-9 (matrix metalloproteinase-9), a marker of atherosclerosis previously reported to be associated with NADPH oxidase overactivity, was quantified by ELISA in plasma samples. The distribution of genotypes was in Hardy-Weinberg equilibrium. The I/D polymorphism was not associated with hypertension. NADPH oxidase-dependent O(2)(*-) production was significantly higher in D/D (deletion/deletion) than in I/I (insertion/insertion) and I/D, both in normotensive and hypertensive subjects. Interestingly, plasma levels of angiotensin II were significantly higher in D/D than in I/I and I/D, both in normotensive and hypertensive subjects. Plasma levels of MMP-9 and systolic blood pressure values were significantly higher in D/D than in I/I and I/D hypertensive subjects, whereas no differences were found among genotypes in normotensive subjects. Interestingly, NADPH oxidase-dependent O(2)(*-) production positively associated with plasma MMP-9 levels in hypertensive subjects, which remained significant after adjustment for age and gender. In conclusion, in the present study we have reported for the first time an association of the D/D genotype of the ACE I/D polymorphism with phagocytic NADPH oxidase-mediated O(2)(*-) overproduction. Within the group of hypertensive patients, D/D cases also associated with increased blood pressure values and with enhanced plasma levels of MMP-9. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Portland Press | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Angiotensin-converting enzyme (ACE) | es_ES |
dc.subject | Essential hypertension | es_ES |
dc.subject | I/D polymorphism | es_ES |
dc.subject | Matrix metalloproteinase-9 (MMP-9) | es_ES |
dc.subject | NADPH oxidase | es_ES |
dc.subject | Superoxide | es_ES |
dc.title | The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.clinsci.org/cs/116/cs1160233.htm | es_ES |
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