Full metadata record
DC Field | Value | Language |
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dc.creator | Roman-Gomez, J. (José) | - |
dc.creator | Jimenez-Velasco, A. (A.) | - |
dc.creator | Agirre-Ena, X. (Xabier) | - |
dc.creator | Castillejo, J.A. (J.A.) | - |
dc.creator | Navarro, G. (Germán) | - |
dc.creator | Calasanz-Abinzano, M.J. (Maria Jose) | - |
dc.creator | Garate, L. (Leire) | - |
dc.creator | San-Jose-Eneriz, E. (Edurne) | - |
dc.creator | Cordeu, L. (Lucía) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.creator | Heiniger, A. (A.) | - |
dc.creator | Torres, A. (Antonio) | - |
dc.date.accessioned | 2011-06-01T14:22:54Z | - |
dc.date.available | 2011-06-01T14:22:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Roman-Gomez, J., Jimenez-Velasco, A., Agirre, X., Castillejo, J. A. et al. CpG IslandMethylator Phenotype Redefines the Prognostic Effect of t(12;21) in Childhood Acute Lymphoblastic Leukemia. Clin Cancer Res 2006; 12; 4845 | es_ES |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18358 | - |
dc.description.abstract | Purpose: To examine cancer genes undergoing epigenetic inactivation in a set of ETV6/ RUNX1-positive acute lymphoblastic leukemias in order to define the CpG island methylator phenotype (CIMP) in the disease and evaluate its relationship with clinical features and outcome. Experimental Design: Methylation-specific PCRwas used to analyze themethylation status of 38 genes involved in cell immortalization and transformation in 54 ETV6/RUNX1-positive samples in comparison with190 ETV6/RUNX1-negative samples. Results: ETV6/RUNX1-positive samples had at least one gene methylated in 89% of the cases. According to the number of methylated genes observed in each individual sample, 20 patients (37%) were included in the CIMP group (0-2 methylated genes) and 34 (67%) in the CIMP+ group (>2 methylated genes). Remission rate did not differ significantly among either group of patients. Estimated disease-free survival and overall survival at 9 years were 92% and 100% for the CIMP group and 33% and 73% for the CIMP+ group (P =0.002andP = 0.04, respectively). Multivariate analysis showed that methylation profile was an independent prognostic factor in predicting disease-free survival (P = 0.01) and overall survival (P = 0.05). A group of four genes (DKK3, sFRP2, PTEN, andP73) showed specificity for ETV6/RUNX1-positive subset of samples. Conclusion: Our results suggest that methylation profile may be a potential new biomarker of risk prediction in ETV6/RUNX1-positive acute lymphoblastic leukemias. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for Cancer Research | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | CpG IslandMethylator Phenotype Redefines the Prognostic Effect of t(12;21) in Childhood Acute Lymphoblastic Leukemia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1158/1078-0432.CCR-05-2592 | es_ES |
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