Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Diaz-Gonzalez, J.A. (Juan Antonio) | - |
dc.creator | Russell, J. (James) | - |
dc.creator | Rouzaut, A. (Ana) | - |
dc.creator | Gil-Bazo, I. (Ignacio) | - |
dc.creator | Montuenga-Badia, L.M. (Luis M.) | - |
dc.date.accessioned | 2011-08-19T10:31:00Z | - |
dc.date.available | 2011-08-19T10:31:00Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Diaz-Gonzalez JA, Russell J, Rouzaut A, Gil-Bazo I, Montuenga L. Targeting hypoxia and angiogenesis through HIF-1alpha inhibition. Cancer Biol Ther 2005 Oct;4(10):1055-1062. | es_ES |
dc.identifier.issn | 1538-4047 | - |
dc.identifier.uri | https://hdl.handle.net/10171/18805 | - |
dc.description.abstract | Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1alpha plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the "angiogenic switch". HIF-1alpha contributes to tumor aggressiveness, invasiveness, and resistance to radiotherapy and chemotherapy. Targeting HIF-1alpha is an attractive strategy, with the potential for disrupting multiple pathways crucial for tumor growth. We review recent findings on the potential efficacy of small molecules to downregulate HIF-1alpha. These promising drugs inhibit HIF-1alpha synthesis or transcriptional activity by blocking a variety of steps in several different signaling pathways. Blocking HIF-1alpha activity should not only downregulate tumor angiogenesis, but also interfere with glycolytic metabolism and tumor cell growth. This strategy could also improve the efficiency of established tumor therapies. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Landes Bioscience | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hypoxia | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | HIF-1a | es_ES |
dc.subject | Molecular inhibitors | es_ES |
dc.subject | Targeted therapy | es_ES |
dc.subject | Molecular imaging | es_ES |
dc.subject | Molecular therapy | es_ES |
dc.title | Targeting hypoxia and angiogenesis through HIF-1alpha inhibition | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.landesbioscience.com/journals/cbt/article/2195/ | es_ES |
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