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dc.creatorGarcia-Diaz, D.F. (Diego F.)
dc.creatorCampión-Zabalza, J. (Javier)
dc.creatorQuintero, P. (Pablo)
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)
dc.creatorMoreno-Aliaga, M. J. (María Jesús)
dc.creatorMartinez, J.A. (José Alfredo)
dc.date.accessioned2011-10-17T15:35:50Z-
dc.date.available2011-10-17T15:35:50Z-
dc.date.issued2011-
dc.identifier.citationGarcia-Diaz DF, Campion J, Quintero P, Milagro FI, Moreno-Aliaga MJ, Martinez JA. Vitamin C modulates the interaction between adipocytes and macrophages. Mol Nutr Food Res. 2011 Sep;55 Suppl 2:S257-63.es_ES
dc.identifier.issn1613-4125-
dc.identifier.urihttps://hdl.handle.net/10171/19173-
dc.description.abstractScope: Increased adiposity is related with monocyte infiltration into the adipose tissue that accentuates inflammation. Antioxidant treatments emerge as approaches to counteract this phenomenon. Methods and results: Cocultures of differentiated 3T3-L1 adipocytes and RAW264.7 macrophages were incubated for 24-72 h with/without 100 nM insulin and/or 200 μM vitamin C (VC). Nitric oxide (NO) secretion (24 h) was measured. Also, expression (24 h) and secretion (72 h) of MCP-1, leptin and apelin were analyzed. NO secretion was significantly inhibited by insulin and VC only in cocultures. MCP-1 expression/secretion was enhanced in cocultures. Insulin incubation reduced MCP-1 expression in both cultures and VC only in controls. Both treatments inhibited MCP-1 secretion in cocultures. Apelin gene expression was induced in cocultures. Insulin induced apelin mRNA expression, but VC inhibited its expression in cocultures under insulin treatment. Apelin secretion was notably induced by insulin and inhibited by VC in cocultures. Leptin expression was decreased in coculture, while presented no effects by VC. Conclusion: VC importantly modulates the established pro-inflammatory state in the interaction between adipocytes and macrophages.es_ES
dc.language.isoenges_ES
dc.publisherWiley Blackwelles_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAscorbic acides_ES
dc.subjectCell culturees_ES
dc.subjectInflammationes_ES
dc.subjectObesityes_ES
dc.titleVitamin C modulates the interaction between adipocytes and macrophageses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp://dx.doi.org/10.1002/mnfr.201100296es_ES

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