Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Diez-Martinez, J. (Javier) | - |
dc.creator | Alonso, A. (Amalia) | - |
dc.creator | Garciandia, A. (Ana) | - |
dc.creator | Lopez, R. (Rafael) | - |
dc.creator | Gomez-Alamillo, C. (Carlos) | - |
dc.creator | Arrazola, A. (Arantxa) | - |
dc.creator | Fortuño, A. (Ana) | - |
dc.date.accessioned | 2011-12-02T13:54:45Z | - |
dc.date.available | 2011-12-02T13:54:45Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Diez J, Alonso A, Garciandia A, Lopez R, Gomez-Alamillo C, Arrazola A, et al. Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension. Am J Hypertens 1995 Feb;8(2):124-132. | es_ES |
dc.identifier.issn | 0895-7061 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20100 | - |
dc.description.abstract | The goal of this study was to investigate the activity of the Na+/H+ exchanger in erythrocytes of patients with essential hypertension and its relation with urinary Na+ excretion. The study was performed in cells from 27 untreated hypertensive patients and 30 normotensive controls with similar age and sex distribution. All subjects were studied after 4 days on a controlled Na+ diet (145 mmol/day). The activity of the Na+/H+ exchanger was determined by acidifying cell pH and measuring the initial rate of the net Na(+)-dependent H+ efflux. The activity of the Na+/H+ exchanger was higher in hypertensive patients than in controls (301 +/- 45 v 162 +/- 23 mmol/L cells/h, mean +/- SEM; P < .01). With the upper limit of the normotensive population as a cut-off point (385 mmol/L cells/h), a subgroup of 12 hypertensive patients had an abnormally high activity of Na+/H+ exchanger. Compared with controls and with patients with normal exchanger activity, patients with increased exchanger activity were characterized by lower net (P < .01) and fractional (P < .05) Na+ excretion. The accumulative Na+ balance was higher (P < .01) in hypertensive patients with increased activity of the exchanger (39.90 +/- 3.47 mmol) than in the remaining hypertensive patients (0.59 +/- 6.96 mmol) or in the normotensive population (-5.71 +/- 6.12 mmol). After analyzing the relationship of renin activity with Na+ excretion it was observed that renin activity was inappropriately low in 9 (75%) patients with increased exchanger, in 6 (40%) patients with normal exchanger, and in 6 (20%) normotensives, these differences being significant (P<.01). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature publishing group | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Erythrocytes/metabolism | es_ES |
dc.subject | Hypertension/blood | es_ES |
dc.subject | Sodium/urine | es_ES |
dc.subject | Sodium-Hydrogen Antiporter/blood | es_ES |
dc.title | Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/0895-7061(94)00172-8 | es_ES |
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