Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Lostao, M.P. (María Pilar) | - |
dc.creator | Urdaneta, E. (Elena) | - |
dc.creator | Martinez-Anso, E. (Eduardo) | - |
dc.creator | Barber, A. (Ana) | - |
dc.creator | Martinez, J.A. (José Alfredo) | - |
dc.date.accessioned | 2011-12-19T12:52:14Z | - |
dc.date.available | 2011-12-19T12:52:14Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Lostao MP, Urdaneta E, Martinez-Anso E, Barber A, Martinez JA. Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 1998 Feb 27;423(3):302-306. | es_ES |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10171/20252 | - |
dc.description.abstract | Leptin is involved in food intake and thermogenesis regulation. Since leptin receptor expression has been found in several tissues including small intestine, a possible role of leptin in sugar absorption by the intestine was investigated. Leptin inhibited D-galactose uptake by rat small intestinal rings 33% after 5 min of incubation. The inhibition increased to 56% after 30 min. However, neither at 5 min nor at 30 min did leptin prevent intracellular galactose accumulation. This leptin effect was accompanied by a decrease of the active sugar transport apparent Vmax (20 vs. 4.8 micromol/g wet weight 5 min) and apparent Km (15.8 vs. 5.3 mM) without any change in the phlorizin-resistant component. On the other hand, immunohistochemical experiments using anti-leptin monoclonal antibodies recognized leptin receptors in the plasma membrane of immune cells located in the lamina propria. These results indicate for the first time that leptin has a rapid inhibitory effect on sugar absorption and demonstrate the presence of leptin receptors in the intestinal mucosa. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Leptin | es_ES |
dc.subject | Sugar absorption | es_ES |
dc.subject | Rat | es_ES |
dc.title | Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/S0014-5793(98)00110-0 | es_ES |
Files in This Item:
There are no files associated with this item.
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.