Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Arribillaga, L. (Laura) | - |
dc.creator | Lopez-Diaz-de-Cerio, A. (Ascensión) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Casares, N. (Noelia) | - |
dc.creator | Gorraiz, M. (Marta) | - |
dc.creator | Vales, A. (África) | - |
dc.creator | Bruña-Romero, O. (Oscar) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.creator | Paranhos-Baccala, G. (Glaucia) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Ruiz, J. (Juan) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.date.accessioned | 2012-01-26T12:55:03Z | - |
dc.date.available | 2012-01-26T12:55:03Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Arribillaga L, de Cerio AL, Sarobe P, Casares N, Gorraiz M, Vales A, et al. Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virus. Vaccine 2002 Dec 13;21(3-4):202-210. | es_ES |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://hdl.handle.net/10171/20615 | - |
dc.description.abstract | Cellular immune response plays an important role in the clearance of hepatitis C virus (HCV). Thus, development of efficient ways to induce anti-viral cellular immune responses is an important step toward prevention and/or treatment of HCV infection. With this aim, we have constructed a replication-deficient recombinant adenovirus expressing HCV NS3 protein (RAdNS3). The efficacy of RAdNS3 was tested in vivo by measuring the protection against infection with a recombinant vaccinia virus expressing HCV-polyprotein (vHCV1-3011). Immunisation with 10(9)pfu of RAdNS3 induced anti-NS3 humoral, T helper and T cytotoxic responses. We identified eight epitopes recognised by IFN-gamma producing cells, five of them exhibiting lytic activity. Moreover, we show that RAdNS3 immunised mice were protected against challenge with vHCV1-3011 and that this protection was mediated by CD8(+) cells. In conclusion, our results suggest that adenoviral vectors encoding NS3 might be useful for the induction of prophylactic and/or therapeutic anti-HCV immunity. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Recombinant adenovirus | es_ES |
dc.subject | Hepatitis C virus | es_ES |
dc.subject | In vivo protection | es_ES |
dc.title | Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virus | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1016/S0264-410X(02)00456-5 | es_ES |
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