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dc.creatorRubio, A. (Ángel)-
dc.creatorGuruceaga, E. (Elizabeth)-
dc.creatorVazquez-Chantada, M. (Mercedes)-
dc.creatorSandoval, J. (Juan)-
dc.creatorMartinez-Cruz, L.A. (L. Alfonso)-
dc.creatorSegura, V. (Víctor)-
dc.creatorSevilla, J.L. (José L.)-
dc.creatorPodhorski, A. (Adam)-
dc.creatorCorrales, F.J. (Fernando José)-
dc.creatorTorres, L. (Luis)-
dc.creatorRodriguez, M. (Manuel)-
dc.creatorAillet, F. (Fabienne)-
dc.creatorAriz, U. (Usue)-
dc.creatorMartinez-Arrieta, F. (Félix)-
dc.creatorCaballeria, J. (Juan)-
dc.creatorMartin-Duce, A. (Antonio)-
dc.creatorLu, S.C. (Shelly C.)-
dc.creatorMartinez-Chantar, M.L. (María Luz)-
dc.creatorMato, J.M. (José María)-
dc.date.accessioned2012-04-03T11:26:31Z-
dc.date.available2012-04-03T11:26:31Z-
dc.date.issued2007-
dc.identifier.citationRubio A, Guruceaga E, Vazquez-Chantada M, Sandoval J, Martinez-Cruz LA, Segura V, et al. Identification of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol 2007 Apr;46(4):708-718.es_ES
dc.identifier.issn1600-0641-
dc.identifier.urihttps://hdl.handle.net/10171/21548-
dc.description.abstractBACKGROUND/AIMS: We have integrated gene expression profiling of liver biopsies of NASH patients with liver samples of a mouse model of steatohepatitis (MAT1A-KO) to identify a gene-pathway associated with NASH. METHODS: Affymetrix U133 Plus 2.0 microarrays were used to evaluate nine patients with NASH, six patients with steatosis, and six control subjects; Affymetrix MOE430A microarrays were used to evaluate wild-type and MAT1A-KO mice at 15 days, 1, 3, 5 and 8 months after birth. Transcriptional profiles of patients with NASH and MAT1A-KO mice were compared with those of their proficient controls. RESULTS: We identified a gene-pathway associated with NASH, that accurately distinguishes between patients with early-stage NASH and controls. Patients with steatosis have a gene expression pattern intermediate between that of NASH and controls. Promoter analysis revealed that 34 of the genes associated with NASH contained an Sp1 element. We found that Sp1 binding to these genes is increased in MAT1A-KO mice. Sp1 is also hyperphosphorylated in MAT1A-KO as well as in patients with NASH and steatosis. CONCLUSIONS: A gene-pathway associated with NASH has been identified. We speculate that hyperphosphorylation of Sp1 may be involved in the genesis of steatosis and that other factors, such as oxidative stress, may trigger its progression to NASH.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectGene-pathwayes_ES
dc.subjectNon-alcoholic steatohepatitises_ES
dc.subjectS-adenosylmethioninees_ES
dc.subjectSp1es_ES
dc.titleIdentification of a gene-pathway associated with non-alcoholic steatohepatitises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S016882780600609Xes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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