Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Font, M. (María) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Alvarez, E. (E.) | - |
dc.creator | Cuartero, A. (A) | - |
dc.creator | Losa, M.J. (M.J.) | - |
dc.creator | Fidalgo, M.J. (M. J.) | - |
dc.creator | Sanmartin-Grijalba, C. (Carmen) | - |
dc.creator | Nadal, E. (Ernest) | - |
dc.creator | Ruiz, I. (I) | - |
dc.creator | Merino, I. (Isidro) | - |
dc.creator | Martinez-Irujo, J.J. (Juan José) | - |
dc.creator | Alberdi, E. (Elena) | - |
dc.creator | Santiago, E. (Esteban) | - |
dc.creator | Prieto, I. (Inés) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-04T09:42:01Z | - |
dc.date.available | 2012-04-04T09:42:01Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Font M, Monge A, Alvarez E, Cuartero A, Losa MJ, Fidalgo MJ, et al. Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives. Drug Des Discov 1997 Apr;14(4):305-332. | es_ES |
dc.identifier.issn | 1029-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21594 | - |
dc.description.abstract | The synthesis and preliminary evaluation of new quinoline and quinoxaline derivatives (obtained by applying the original Reissert method, conveniently modified) as HIV-1 Reverse Transcriptase (RT) inhibitors are presented in this paper; likewise, the first structure-activity relationships are also proposed. Propyl 2-cyano-1(2H)-quinolin-carboxylate 2e, isopropyl 2-cyano-1 (2H)-quinolincarboxylate 2f, butyl 2-cyano-1 (2H)-quinolincarboxylate 2g and isobutyl 2-cyano-1 (2H)-quinolincarboxylate 2h have been selected as lead compounds. These compounds are active against the HIV-1 RT mutant type P236L (2f, IC50 = 1.2 microM) and present activity as anti-infective agents in HLT41acZ-1IIIB cells, showing no cytotoxicity at the active concentrations. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Gordon and Breach | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | Anti-HIV Agents/chemical synthesis | es_ES |
dc.subject | HIV Reverse Transcriptase/antagonists & inhibitors | es_ES |
dc.subject | Quinolines/chemical synthesis | es_ES |
dc.subject | Quinoxalines/chemical synthesis | es_ES |
dc.subject | Reverse Transcriptase Inhibitors/chemical synthesis | es_ES |
dc.title | Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://cat.inist.fr/?aModele=afficheN&cpsidt=2673751 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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