Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Hervas-Stubbs, S. (Sandra) | - |
dc.creator | Berasain, C. (Carmen) | - |
dc.creator | Golvano, J.J. (José Javier) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Prieto, I. (Isidro) | - |
dc.creator | Sarobe, P. (Pablo) | - |
dc.creator | Prieto, J. (Jesús) | - |
dc.creator | Borras-Cuesta, F. (Francisco) | - |
dc.date.accessioned | 2012-04-04T12:17:00Z | - |
dc.date.available | 2012-04-04T12:17:00Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Hervas-Stubbs S, Berasain C, Golvano JJ, Lasarte JJ, Prieto I, Sarobe P, et al. Overcoming class II-linked non-responsiveness to hepatitis B vaccine. Vaccine 1994 Aug;12(10):867-871. | es_ES |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21603 | - |
dc.description.abstract | This work shows that class II-linked humoral lack of response to an antigen can be overcome by joint immunization with the antigen and a T-helper cell determinant (TDh) well recognized by class II molecules of a non-responder individual. Thus, SJL/J mice (H-2s), which are non-responders to the S region of hepatitis B virus surface antigen (HBsAg), were rendered responders by joint immunization with a recombinant surface antigen, only composed of the S region, and a short synthetic TDh peptide well recognized by the H-2s restriction. By contrast, when this peptide is not recognized as TDh, as in B10M mice (H-2f restricted and also non-responders to the S region), no humoral response could be induced against the S region. These results have important implications for therapy and vaccination against hepatitis B virus as well as in enhancing the immunogenicity of other antigens. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Hepatitis B surface antigen | es_ES |
dc.subject | T-cell help | es_ES |
dc.subject | Hepatitis B vaccine | es_ES |
dc.subject | Induction of antibodies | es_ES |
dc.subject | Synthetic peptides | es_ES |
dc.title | Overcoming class II-linked non-responsiveness to hepatitis B vaccine | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/0264410X94900264 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.