Full metadata record
DC Field | Value | Language |
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dc.creator | San-Roman, B. (Beatriz) | - |
dc.creator | Andres, X. (Ximena) de | - |
dc.creator | Muñoz, P. (Pilar) | - |
dc.creator | Obregon, P. (Patricia) | - |
dc.creator | Asensio, A.C. (Aaron C.) | - |
dc.creator | Garrido, V. (Victoria) | - |
dc.creator | Mansilla, C. (Cristina) | - |
dc.creator | Arribillaga, L. (Laura) | - |
dc.creator | Lasarte, J.J. (Juan José) | - |
dc.creator | Andres, D. (D.) de | - |
dc.creator | Amorena, B. (Beatriz) | - |
dc.creator | Grillo, M.J. (María Jesús) | - |
dc.date.accessioned | 2012-04-23T07:39:33Z | - |
dc.date.available | 2012-04-23T07:39:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | San Roman B, De Andres X, Munoz PM, Obregon P, Asensio AC, Garrido V, et al. The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model. Vaccine 2012 Mar 28;30(15):2564-2569. | es_ES |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21715 | - |
dc.description.abstract | The development of effective vaccines against HIV-1 infection constitutes one of the major challenges in viral immunology. One of the protein candidates in vaccination against this virus is p24, since it is a conserved HIV antigen that has cytotoxic and helper T cell epitopes as well as B cell epitopes that may jointly confer enhanced protection against infection when used in immunization-challenge approaches. In this context, the adjuvant effect of EDA (used as EDAp24 fusion protein) and poly(I:C), as agonists of TLR4 and TLR3, respectively, was assessed in p24 immunizations using a recombinant Listeria monocytogenes HIV-1 Gag proteins (Lm-Gag, where p24 is the major antigen) for challenge in mice. Immunization with EDAp24 fusion protein together with poly(I:C) adjuvant induced a specific p24 IFN-γ production (Th1 profile) as well as protection against a Lm-Gag challenge, suggesting an additive or synergistic effect between both adjuvants. The combination of EDA (as a fusion protein with the antigen, which may favor antigen targeting to dendritic cells through TLR4) and poly(I:C) could thus be a good adjuvant candidate to enhance the immune response against HIV-1 proteins and its use may open new ways in vaccine investigations on this virus. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | EDA | es_ES |
dc.subject | Adjuvants | es_ES |
dc.subject | HIV | es_ES |
dc.subject | p24 | es_ES |
dc.subject | Vaccine | es_ES |
dc.subject | Mice | es_ES |
dc.title | The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0264410X12001429 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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