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dc.creatorSangro, B. (Bruno)-
dc.creatorMazzolini, G. (Guillermo)-
dc.creatorRuiz, J. (Juan)-
dc.creatorHerraiz-Bayod, M.J. (Maite J.)-
dc.creatorQuiroga, J. (Jorge)-
dc.creatorHerrero, J.I. (José Ignacio)-
dc.creatorBenito-Boilos, A. (Alberto)-
dc.creatorLarrache, J. (Javier)-
dc.creatorPueyo, J. (Jesús)-
dc.creatorSubtil, J.C. (José Carlos)-
dc.creatorOlagüe, C. (Cristina)-
dc.creatorSola, J. (Josu)-
dc.creatorSadaba, B. (Belén)-
dc.creatorLacasa, C. (Carlos)-
dc.creatorMelero, I. (Ignacio)-
dc.creatorQian, C. (Cheng)-
dc.creatorPrieto, J. (Jesús)-
dc.date.accessioned2012-04-25T09:45:47Z-
dc.date.available2012-04-25T09:45:47Z-
dc.date.issued2004-
dc.identifier.citationSangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I, et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol 2004 Apr 15;22(8):1389-1397.es_ES
dc.identifier.issn1527-7755-
dc.identifier.urihttps://hdl.handle.net/10171/21791-
dc.description.abstractPURPOSE: To evaluate the feasibility and safety of intratumoral injection of an adenoviral vector encoding human interleukin-12 genes (Ad.IL-12) and secondarily, its biologic effect for the treatment of advanced digestive tumors. PATIENTS AND METHODS: Ad.IL-12 was administered in doses ranging from 2.5 x 10(10) to 3 x 10(12) viral particles, to seven cohorts of patients with advanced pancreatic, colorectal, or primary liver malignancies. Patients were thoroughly assessed for toxicity, and antitumor response was evaluated by imaging techniques, tumor biopsy, and hypersensitivity skin tests. Patients with stable disease and no serious adverse reactions were allowed to receive up to 3 monthly doses of Ad.IL-12. RESULTS: Twenty-one patients (nine with primary liver, five with colorectal, and seven with pancreatic cancers) received a total of 44 injections. Ad.IL-12 was well tolerated, and dose-limiting toxicity was not reached. Frequent but transient adverse reactions, including fever, malaise, sweating, and lymphopenia, seemed to be related to vector injection rather than to transgene expression. No cumulative toxicity was observed. In four of 10 assessable patients, a significant increase in tumor infiltration by effector immune cells was apparent. A partial objective remission of the injected tumor mass was observed in a patient with hepatocellular carcinoma. Stable disease was observed in 29% of patients, mainly those with primary liver cancer. CONCLUSION: Intratumoral injection of up to 3 x 10(12) viral particles of Ad.IL-12 to patients with advanced digestive malignancies is a feasible and well-tolerated procedure that exerts only mild antitumor effects.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society of Clinical Oncologyes_ES
dc.rightsinfo:eu-repo/semantics/closedAccess-
dc.subjectDigestive System Neoplasms/therapyes_ES
dc.subjectInterleukin-12/geneticses_ES
dc.subjectInterleukin-12/therapeutic usees_ES
dc.titlePhase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://jco.ascopubs.org/content/22/8/1389es_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

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