The endothelial cell protein C receptor: its role in thrombosis
Activated protein C
Endothelial protein C receptor
Factor VII
Venous thrombosis
Myocardial infarction
Issue Date: 
Navarro S, Bonet E, Estelles A, Montes R, Hermida J, Martos L, et al. The endothelial cell protein C receptor: its role in thrombosis. Thromb Res 2011 Nov;128(5):410-416.
The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts cytoprotective effects through endothelial protein C receptor binding. An adequate generation of activated protein C depends on the precise assembly, on the surface of the endothelial cells, of thrombin, thrombomodulin, protein C, and endothelial protein C receptor. Therefore, any change in the efficiency of this assembly may cause a reduction or increase in activated protein C generation and modulate the risk of thrombosis. This review highlights the role of the endothelial protein C receptor in disease and discusses the association of its mutations with the risk of thrombosis.

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