Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Van-Hylckama-Vlieg, A. (A) | - |
dc.creator | Montes, R. (Ramón) | - |
dc.creator | Rosendaal, F.R. (F.R.) | - |
dc.creator | Hermida, J. (José) | - |
dc.date.accessioned | 2012-05-10T14:35:51Z | - |
dc.date.available | 2012-05-10T14:35:51Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Van Hylckama Vlieg A, Montes R, Rosendaal FR, Hermida J. Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis. J Thromb Haemost 2007 Jul;5(7):1449-1454. | es_ES |
dc.identifier.issn | 1538-7836 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21988 | - |
dc.description.abstract | BACKGROUND: The endothelial protein C receptor (EPCR) binds protein C and enhances its activation. Anti-EPCR autoantibodies are found in patients with antiphospholipid syndrome and may explain the increased risk of thrombosis in these patients. Anti-EPCR autoantibodies have been associated with fetal death and myocardial infarction in young women. OBJECTIVES: To determine whether anti-EPCR autoantibodies are associated with deep vein thrombosis (DVT). PATIENTS/METHODS: We measured plasma anti-EPCR autoantibody levels in the Leiden Thrombophilia Study (LETS), a population-based case-control study consisting of 474 patients with a first DVT and 474 control subjects. RESULTS: The estimated risk of DVT was increased approximately 2-fold in the presence of elevated IgA, IgG or IgM anti-EPCR autoantibodies (i.e. levels above the 90th percentile as measured in the control subjects). The risk conferred by anti-EPCR increased in a dose-dependent manner for IgA and IgG. When anti-EPCR autoantibodies were considered in the co-presence of lupus anticoagulant (LAC) the odds ratio (OR) was 6.1 [95% CI 1.3-27.9]. Anti-EPCR without LAC remained associated with DVT (OR 1.6; 95% CI 1.2-2.1). Anti-EPCR autoantibodies were associated with high levels of D-dimer and soluble EPCR in controls, suggestive of a prothrombotic status induced by the autoantibodies. CONCLUSIONS: This study demonstrates that the presence of anti-EPCR autoantibodies is a moderate risk factor for DVT in the general population. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Autoantibodies | es_ES |
dc.subject | Deep vein thrombosis | es_ES |
dc.subject | Endothelial protein C receptor | es_ES |
dc.subject | Lupus anticoagulant | es_ES |
dc.subject | Risk factors | es_ES |
dc.title | Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2007.02582.x/abstract | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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