Full metadata record
DC FieldValueLanguage
dc.creatorGomez-Ambrosi, J. (Javier)-
dc.creatorSalvador, J. (Javier)-
dc.creatorParamo, J.A. (José Antonio)-
dc.creatorOrbe, J. (Josune)-
dc.creatorIrala, J. (Jokin) de-
dc.creatorDiez-Caballero, A. (Alberto)-
dc.creatorGil, M.J. (María José)-
dc.creatorÁlvarez-Cienfuegos, J. (Javier)-
dc.creatorFrühbeck, G. (Gema)-
dc.date.accessioned2012-05-28T15:02:24Z-
dc.date.available2012-05-28T15:02:24Z-
dc.date.issued2002-
dc.identifier.citationGomez-Ambrosi J, Salvador J, Paramo JA, Orbe J, de Irala J, Diez-Caballero A, et al. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem 2002 Jun;35(4):315-320.es_ES
dc.identifier.issn1873-2933-
dc.identifier.urihttps://hdl.handle.net/10171/22243-
dc.description.abstractOBJECTIVES: Recent epidemiologic studies have shown that obesity is associated with elevated blood concentrations of prothrombotic-proinflammatory factors and markers of endothelial dysfunction such as fibrinogen, C-reactive protein (CRP), von Willebrand factor (vWF), and homocysteine. We have assessed whether these markers are associated with percentage of body fat (BF), insulin sensitivity as well as with leptin concentrations. DESIGN AND METHODS: Twenty-five men aged 49.6 +/- 12.7 yr (mean +/- SD) underwent whole-body air displacement plethysmography (Bod-Pod(R)) for estimating BF. Blood analyses for leptin and several other metabolic and cardiovascular markers were carried out. RESULTS: Obese subjects had higher levels as compared to controls of BF (37.5 +/- 5.1 vs. 26.0 +/- 6.6, p < 0.01), fibrinogen (3.30 +/- 0.43 vs. 2.67 +/- 0.11, p < 0.01), vWF (136.4 +/- 50.4% vs. 81.6 +/- 12.6%, p < 0.05), and leptin (17.6 +/- 8.7 vs. 6.2 +/- 3.3, p < 0.01), lower concentrations of HDL-cholesterol (1.09 +/- 0.20 vs. 1.51 +/- 0.10, p < 0.001) and lower QUICKI (1/[log(Ins(0)) + log(Glu(0))]) (0.31 +/- 0.03 vs. 0.34 +/- 0.02, p < 0.05). No significant changes were observed in CRP (5.7 +/- 3.4 vs. 3.8 +/- 1.6, p = 0.327) and homocysteine (9.4 +/- 4.2 vs. 8.3 +/- 0.9, p = 0.749). A positive correlation was observed between BF and fibrinogen (r = 0.67, p = 0.0003). Plasma leptin concentrations were correlated with fibrinogen (r = 0.71, p = 0.0001) and CRP (r = 0.43, p = 0.044). After adjustment for BF leptin emerged as a significant predictor of fibrinogen (beta = 0.47, p = 0.023; R(2) = 0.59, p < 0.001). QUICKI was positively correlated with HDL-cholesterol (r = 0.59, p = 0.010) and negatively with fibrinogen (r = -0.53, p = 0.025), CRP (r = -0.52, p = 0.028) and vWF (r = -0.56, p = 0.013). CONCLUSIONS: Increased BF and impaired insulin sensitivity are associated with increased concentrations of cardiovascular risk factors. Leptin seems to be involved in this elevation and emerges as a predictor of circulating fibrinogen concentrations.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectObesityes_ES
dc.subjectCardiovascular riskes_ES
dc.subjectLeptines_ES
dc.subjectFibrinogenes_ES
dc.subjectInsulin sensitivityes_ES
dc.titleInvolvement of leptin in the association between percentage of body fat and cardiovascular risk factorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S000991200200320Xes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES

Files in This Item:
Thumbnail
File
ClinicalBiochem2002_35315.pdf
Description
Size
84.08 kB
Format
Adobe PDF


Statistics and impact
0 citas en
0 citas en

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.