Full metadata record
DC Field | Value | Language |
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dc.creator | Lorente, L. (Leonardo) | - |
dc.creator | Martin, M.M. (María M.) | - |
dc.creator | Labarta, L. (Lorenzo) | - |
dc.creator | Díaz, C. (César) | - |
dc.creator | Sole-Violan, J. (Jordi) | - |
dc.creator | Blanquer, J. (José) | - |
dc.creator | Orbe, J. (Josune) | - |
dc.creator | Rodriguez, J.A. (José Antonio) | - |
dc.creator | Jimenez, A. (Alejandro) | - |
dc.creator | Borreguero-Leon, J.M. (Juan María) | - |
dc.creator | Belmonte, F. (Felipe) | - |
dc.creator | Medina, J.C. (Juan C.) | - |
dc.creator | Llimiñana, M.C. (María C.) | - |
dc.creator | Ferrer-Agüero, J.M. (José M.) | - |
dc.creator | Ferreres, J. (José) | - |
dc.creator | Mora, M.L. (María L.) | - |
dc.creator | Lubillo, S. (Santiago) | - |
dc.creator | Sanchez, M. (Manuel) | - |
dc.creator | Barrios, Y. (Ysamar) | - |
dc.creator | Sierra, A. (Antonio) | - |
dc.creator | Paramo, J.A. (José Antonio) | - |
dc.date.accessioned | 2012-05-28T15:37:25Z | - |
dc.date.available | 2012-05-28T15:37:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, et al. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care 2009;13(5):R158. | es_ES |
dc.identifier.issn | 1466-609X | - |
dc.identifier.uri | https://hdl.handle.net/10171/22256 | - |
dc.description.abstract | INTRODUCTION: Matrix metalloproteinases (MMPs) play a role in infectious diseases through extracellular matrix (ECM) degradation, which favors the migration of immune cells from the bloodstream to sites of inflammation. Although higher levels of MMP-9 and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) have been found in small series of patients with sepsis, MMP-10 levels have not been studied in this setting. The objective of this study was to determine the predictive value of MMP-9, MMP-10, and TIMP-1 on clinical severity and mortality in a large series of patients with severe sepsis. METHODS: This was a multicenter, observational, and prospective study carried out in six Spanish Intensive Care Units. We included 192 (125 surviving and 67 nonsurviving) patients with severe sepsis and 50 age- and sex-matched healthy controls in the study. Serum levels of MMP-9, MMP-10, TIMP-1, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10 were measured in patients with severe sepsis at the time of diagnosis and in healthy controls. RESULTS: Sepsis patients had higher levels of MMP-10 and TIMP-1, higher MMP-10/TIMP-1 ratios, and lower MMP-9/TIMP-1 ratios than did healthy controls (P < 0.001). An association was found between MMP-9, MMP-10, TIMP-1, and MMP-9/TIMP-1 ratios and parameters of sepsis severity, assessed by the SOFA score, the APACHE-II score, lactic acid, platelet count, and markers of coagulopathy. Nonsurviving sepsis patients had lower levels of MMP-9 (P = 0.037), higher levels of TIMP-1 (P < 0.001), lower MMP-9/TIMP-1 ratio (P = 0.003), higher levels of IL-10 (P < 0.001), and lower TNF-alpha/IL-10 ratio than did surviving patients. An association was found between MMP-9, MMP-10, and TIMP-1 levels, and TNF-alpha and IL-10 levels. The risk of death in sepsis patients with TIMP-1 values greater than 531 ng/ml was 80% higher than that in patients with lower values (RR = 1.80; 95% CI = 1.13 to 2.87;P = 0.01; sensitivity = 0.73; specificity = 0.45). CONCLUSIONS: The novel findings of our study on patients with severe sepsis (to our knowledge, the largest series reporting data about MMP levels in sepsis) are that reduced MMP-9/TIMP-1 ratios and increased MMP-10 levels may be of great pathophysiologic significance in terms of severity and mortality, and that TIMP-1 levels may represent a biomarker to predict the clinical outcome of patients with sepsis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Matrix metalloproteinase 10/blood | es_ES |
dc.subject | Matrix metalloproteinase 9/blood | es_ES |
dc.subject | Sepsis/mortality | es_ES |
dc.subject | Sepsis/physiopathology | es_ES |
dc.subject | Severity of illness Index | es_ES |
dc.subject | Tissue inhibitor of metalloproteinase-1/blood | es_ES |
dc.title | Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://ccforum.com/content/13/5/R158 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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