Gastaminza G, de la Borbolla JM, Goikoetxea MJ, Escudero R, Anton J, Espinos J, et al. A new rapid desensitization protocol for chemotherapy agents. J Investig Allergol Clin Immunol 2011;21(2):108-112.
Background: Desensitization has been used for some decades to treat patients with the allergenic drug when an alternative drug with
similar effi cacy and safety is not available. We present the results from a series of oncology patients desensitized at our hospital during
the last 2 years.
Objective: To assess the effi cacy of a new desensitization protocol in patients allergic to chemotherapy drugs.
Methods: We performed an observational retrospective study of 11 women (6 breast cancer and 5 ovarian cancer) who underwent our
desensitization protocol. Four patients had immediate reactions to carboplatin, 3 to docetaxel, 3 to paclitaxel, and 1 to both docetaxel
and paclitaxel. Premedication was administered in all cases. A 5-step protocol based on 5 different dilutions of the drugs was used.
Results: We performed 39 desensitization procedures: 14 to carboplatin, 3 to oxaliplatin, 16 to docetaxel, and 6 to paclitaxel. Eight patients
tolerated the full dose in 36 procedures. One patient suffered an anaphylactic reaction to carboplatin that reverted with treatment. One
patient had dyspnea after a paclitaxel cycle. One patient experienced dyspnea due to chronic pulmonary thromboembolism related to
Conclusion: Desensitization is a useful procedure in patients who are allergic to their chemotherapy agents.