Full metadata record
DC FieldValueLanguage
dc.creatorBoque, N. (Noemi)-
dc.creatorCampión-Zabalza, J. (Javier)-
dc.creatorMilagro-Yoldi, F.I. (Fermín Ignacio)-
dc.creatorMoreno-Aliaga, M. J. (María Jesús)-
dc.creatorMartinez, J.A. (José Alfredo)-
dc.date.accessioned2013-03-29T12:04:27Z-
dc.date.available2013-03-29T12:04:27Z-
dc.date.issued2009-
dc.identifier.citationBoque N, Campion J, Milagro FI, Moreno-Aliaga MJ, Martinez JA. Some cyclin-dependent kinase inhibitors-related genes are regulated by vitamin C in a model of diet-induced obesity. Biol Pharm Bull 2009 Aug;32(8):1462-1468es_ES
dc.identifier.issn0918-6158-
dc.identifier.urihttps://hdl.handle.net/10171/28191-
dc.description.abstractThe aim of this research was to investigate differential gene expression of cyclin-dependent kinase inhibitors (CKIs) in white adipose tissue (WAT) and liver from high-fat fed male Wistar rats with or without vitamin C (VC) supplementation (750 mg/kg of body weight). After 56 d of experimentation, animals fed on a cafeteria diet increased significantly body weights and total body fat. Reverse transcription-polymerase chain reaction (RT-PCR) studies showed that cafeteria diet decreased p21 and p57 mRNA expression in subcutaneous WAT and increased p21 mRNA in liver. Overall, these data provide new information about the role of high fat intake on mRNA levels of several CKIs with implications in adipogenesis, cell metabolism and weight homeostasis. Interestingly, VC supplementation partially prevented diet-induced adiposity and increased p27 mRNA in liver without any changes in the other tissues and genes analyzed. Thus, hepatic mRNA changes induced by ascorbic acid indicate a possible role of these genes in diet-induced oxidative stress processes.es_ES
dc.language.isoenges_ES
dc.publisherPharmaceutical Society of Japanes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCyclin-dependent kinase inhibitores_ES
dc.subjectCafeteria dietes_ES
dc.subjectAscorbic acides_ES
dc.subjectAdipose tissuees_ES
dc.subjectFatty liveres_ES
dc.titleSome cyclin-dependent kinase inhibitors-related genes are regulated by vitamin C in a model of diet-induced obesityes_ES
dc.typeArticuloes_ES
dc.type.driverinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttp://dx.doi.org/10.1248/bpb.32.1462es_ES

Files in This Item:
Thumbnail
File
Martinez2009Japan.pdf
Description
Size
265.68 kB
Format
Adobe PDF


Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.