Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines
Keywords: 
Alkyl-lysophospholipids
Edelfosine
Lipid nanoparticles
Leukemia
Issue Date: 
2013
Publisher: 
Elsevier
ISSN: 
0304-3835
Citation: 
Lasa-Saracíbar B, Estella-Hermoso de Mendoza A, Mollinedo F, Odero MD, Blanco-Príeto MJ. Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines. Cancer Lett 2013 7/1;334(2):302-310
Abstract
Although current therapies have improved leukemia survival rates, adverse drug effects and relapse are frequent. Encapsulation of edelfosine (ET) in lipid nanoparticles (LN) improves its oral bioavailability and decreases its toxicity. Here we evaluated the efficacy of ET-LN in myeloid leukemia cell lines. Drug-loaded LN were as effective as free ET in sensitive leukemia cell lines. Moreover, the encapsulated drug overcame the resistance of the K562 cell line to the drug. LN containing ET might be used as a promising drug delivery system in leukemia due to their capacity to overcome the in vivo pitfalls of the free drug and their efficacy in vitro in leukemia cell lines.

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