RM en el diagnóstico y control evolutivo de la degeneración combinada subaguda. A propósito de un caso
Other Titles: 
MRI in the diagnostic and evolutive control of subacute combined degeneration. A case report
Degeneración combinada subaguda
Médula espinal
Resonancia magnética
Vitamina B12
Issue Date: 
Gobierno de Navarra. Departamento de Salud
Sáiz-Mendiguren R, García-Eulate R, García Lallana A, Irimia P, Martínez Vila EA. RM en el diagnostico y control evolutivo de la degeneracion combinada subaguda. A proposito de un caso. An Sist Sanit Navar. 2012 May-Aug;35(2):329-33.
A deficit of vitamin B12, generally resulting from pernicious anaemia, can give rise to disorders of the spinal cord, brain, optic and peripheral nerves. The principal neurological syndrome is subacute combined degeneration of the spinal cord (SCD), which can cause progressive motor and/or sensitive alterations, instability and incontinency, due to the demyelination of the posterior horn of the spinal cord. The identification by magnetic resonance (MR) of signal hyperintensity in T2 weighted sequences at the level of the posterior horns of the spinal and/or cervical cord can be of great use in diagnosising the patient with SCD, above all when the symptoms are mild or nonspecific, and the patient does not have haematological or gastrointestinal alterations. Besides, the evolution of the altered signal of the posterior horns in MR can be of use in evaluating the efficacy of treatment, since their normalization is related to clinical improvement

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