Pozo, J.del ; Fernández, N. ; Sáez, E. ; Herrero, J. ; Yuste, J.; Bañales, J. ""Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism"" Antimicrobial Agents and Chemotherapy 2014, 58(7):4227.
Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in
patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term
linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.