Full metadata record
DC Field | Value | Language |
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dc.creator | Jacobs, K. (Kevin) | - |
dc.creator | Yeager, M. (Meredith) | - |
dc.creator | Zhou, W. (Weiyin) | - |
dc.creator | Wacholder, S. (Sholom) | - |
dc.creator | Wang, Z. (Zhaoming) | - |
dc.creator | Rodriguez-Santiago, B. (Benjamin) | - |
dc.creator | Hutchinson, A. (Amy) | - |
dc.creator | Deng, X. (Xiang) | - |
dc.creator | Liu, C. (Chenwei) | - |
dc.creator | Horner, M.J. (Marie-Josephe) | - |
dc.creator | Cullen, M. (Michael) | - |
dc.creator | Cook, M.B. (Michael B.) | - |
dc.creator | Graubard, B.I. (Barry I.) | - |
dc.creator | Kratz, C.P. (Christian P.) | - |
dc.creator | Greene, M.H. (Mark H.) | - |
dc.creator | Erickson, R.L. (Ralph L.) | - |
dc.creator | Hunter, D.J. (David J.) | - |
dc.creator | Gapstur, S.M. (Susan M.) | - |
dc.creator | Thomas, G. (Gilles) | - |
dc.creator | Stevens, V.L. (Victoria L.) | - |
dc.creator | Teras, L.R. (Lauren R.) | - |
dc.creator | Michaud, D.S. (Dominique S.) | - |
dc.creator | White, E. (Emily) | - |
dc.creator | Gaudet, M.M. (Mia M.) | - |
dc.creator | Albanes, D. (Demetrius) | - |
dc.creator | Weinstein, S.J. (Stephanie J.) | - |
dc.creator | Virtamo, J. (Jarmo) | - |
dc.creator | Taylor, P.R. (Philip R.) | - |
dc.creator | Freedman, N.D. (Neal D.) | - |
dc.creator | Abnet, C.C. (Christian C.) | - |
dc.creator | Goldstein, A.M. (Alisa M.) | - |
dc.creator | Hu, N. (Nan) | - |
dc.creator | Melin, B.S. (Beatrice S.) | - |
dc.creator | Yu, K. (Kai) | - |
dc.creator | Wolk, A. (Alicja) | - |
dc.creator | Yuan, J.M. (Jian-Min) | - |
dc.creator | Liao, L. (Linda) | - |
dc.creator | Ding, T. (Ti) | - |
dc.creator | Qiao, Y.L. (You-Lin) | - |
dc.creator | Gao, Y.T. (Yu-Tang) | - |
dc.creator | Koh, W.P. (Woon-Puay) | - |
dc.creator | Xiang, Y.B. (Yong-Bing) | - |
dc.creator | Tang, Z.Z. (Ze-Zhong) | - |
dc.creator | Peters, U. (Ulrike) | - |
dc.creator | Fan, J.H. (Jin-Hu) | - |
dc.creator | Aldrich, M.C. (Melinda C.) | - |
dc.creator | Zeleniuch-Jacquotte, A. (Anne) | - |
dc.creator | Amos, C. (Christopher) | - |
dc.creator | Blot, W.J. (William J.) | - |
dc.creator | Bock, C.H. (Cathryn H.) | - |
dc.creator | Gillanders, E.M. (Elizabeth M.) | - |
dc.creator | Harris, C.C. (Curtis C.) | - |
dc.creator | Haiman, C.A. (Christopher A.) | - |
dc.creator | Henderson, B.E. (Brian E.) | - |
dc.creator | Ruder, A.M. (Avima M.) | - |
dc.creator | Kolonel, L.N. (Laurence N.) | - |
dc.creator | Le-Marchand, L. (Loic) | - |
dc.creator | McNeill, L.H. (Lorna H.) | - |
dc.creator | Zheng, W. (Wei) | - |
dc.creator | Rybicki, B.A. (Benjamin A.) | - |
dc.creator | Schwartz, A.G. (Ann G.) | - |
dc.creator | Signorello, L.B. (Lisa B.) | - |
dc.creator | Spitz, M.R. (Margaret R.) | - |
dc.creator | Wiencke, J.K. (John K.) | - |
dc.creator | Wrensch, M. (Margaret) | - |
dc.creator | Sesso, H.D. (Howard D.) | - |
dc.creator | Wu, Y.Q. (Yan Q.) | - |
dc.creator | Zanetti, K.A. (Krista A.) | - |
dc.creator | Ziegler, R.G. (Regina G.) | - |
dc.creator | Figueroa, J.D. (Jonine D.) | - |
dc.creator | Silverman, D.T. (Debra T.) | - |
dc.creator | Garcia-Closas, M. (Montserrat) | - |
dc.creator | Malats, N. (Nuria) | - |
dc.creator | Marenne, G. (Gaelle) | - |
dc.creator | Prokunina-Olsson, L. (Ludmila) | - |
dc.creator | Baris, D. (Dalsu) | - |
dc.creator | Severi, G. (Gianluca) | - |
dc.creator | Schwenn, M. (Molly) | - |
dc.creator | Johnson, A. (Alison) | - |
dc.creator | Landi, M.T. (María Teresa) | - |
dc.creator | Goldin, L. (Lynn) | - |
dc.creator | Consonni, D. (Dario) | - |
dc.creator | Kogevinas, M. (Manolis) | - |
dc.creator | Bertazzi, P.A. (Pier Alberto) | - |
dc.creator | Rotunno, M. (Melissa) | - |
dc.creator | Rajaraman, P. (Preetha) | - |
dc.creator | Andersson, U. (Ulrika) | - |
dc.creator | Shu, X.O. (Xiao-Ou) | - |
dc.creator | Beane-Freeman, L.E. (Laura E.) | - |
dc.creator | Berg, C.D. (Christine D.) | - |
dc.creator | Buring, J.E. (Julie E.) | - |
dc.creator | Butler, M.A. (Mary A.) | - |
dc.creator | Carreon, T. (Tania) | - |
dc.creator | Feychting, M. (Maria) | - |
dc.creator | Gonzalez, J.R. (Juan R.) | - |
dc.creator | Ahlbom, A. (Anders) | - |
dc.creator | Gaziano, J.M. (J. Michael) | - |
dc.creator | Giles, G.G. (Graham G.) | - |
dc.creator | Visvanathan, K. (Kala) | - |
dc.creator | Hallmans, G. (Goran) | - |
dc.creator | Hankinson, S.E. (Susan E.) | - |
dc.creator | Hartge, P. (Patricia) | - |
dc.creator | Henriksson, R. (Roger) | - |
dc.creator | Inskip, P.D. (Peter D.) | - |
dc.creator | Johansen, C. (Christoffer) | - |
dc.creator | Landgren, A. (Annelie) | - |
dc.creator | Villa, O. (Olaya) | - |
dc.creator | McKean-Cowdin, R. (Roberta) | - |
dc.creator | Li, D. (Donghui) | - |
dc.creator | Duell, E.J. (Eric J.) | - |
dc.creator | Hoover, R.N. (Robert N.) | - |
dc.creator | Epstein, C.G. (Caroline G.) | - |
dc.creator | Risch, H.A. (Harvey A.) | - |
dc.creator | Olson, S.H. (Sara H.) | - |
dc.creator | Kooperberg, C. (Charles) | - |
dc.creator | Wolpin, B.M. (Brian M.) | - |
dc.creator | Jiao, L. (Li) | - |
dc.creator | Hassan, M. (Manal) | - |
dc.creator | Wheeler, W. (William) | - |
dc.creator | Arslan, A.A. (Alan A.) | - |
dc.creator | Bueno-de-Mesquita, H.B. (H. Bas) | - |
dc.creator | Real, F.X. (Francisco X.) | - |
dc.creator | Fuchs, C.S. (Charles S.) | - |
dc.creator | Burdett, L. (Laurie) | - |
dc.creator | Gallinger, S. (Steven) | - |
dc.creator | Gross, M.D. (Myron D.) | - |
dc.creator | Holly, E.A. (Elizabeth A.) | - |
dc.creator | Klein, A.P. (Alison P.) | - |
dc.creator | LaCroix, A. (Andrea) | - |
dc.creator | Mandelson, M.T. (Margaret T.) | - |
dc.creator | Petersen, G. (Gloria) | - |
dc.creator | Boutron-Ruault, M.C. (Marie-Christine) | - |
dc.creator | Fraumeni, J.F. (Joseph F.) | - |
dc.creator | Bracci, P.M. (Paige M.) | - |
dc.creator | Canzian, F. (Federico) | - |
dc.creator | Dean, M.C. (Michael C.) | - |
dc.creator | Chang, K. (Kenneth) | - |
dc.creator | Cotterchio, M. (Michelle) | - |
dc.creator | Giovannucci, E.L. (Edward L.) | - |
dc.creator | Goggins, M. (Michael) | - |
dc.creator | Hoffman-Bolton, J.A. (Judith A.) | - |
dc.creator | Jenab, M. (Mazda) | - |
dc.creator | Khaw, K.T. (Kay-Tee) | - |
dc.creator | Caporaso, N.E. (Neil E.) | - |
dc.creator | Krogh, V. (Vittorio) | - |
dc.creator | Kurtz, R.C. (Robert C.) | - |
dc.creator | McWilliams, R.R. (Robert R.) | - |
dc.creator | Chatterjee, N. (Nilanjan) | - |
dc.creator | Mendelsohn, J.B. (Julie B.) | - |
dc.creator | Rabe, K.G. (Kari G.) | - |
dc.creator | Riboli, E. (Elio) | - |
dc.creator | Tjonneland, A. (Anne) | - |
dc.creator | Tobias, G.S. (Geoffrey S.) | - |
dc.creator | Trichopoulos, D. (Dimitrios) | - |
dc.creator | Tucker, M. (Margaret) | - |
dc.creator | Elena, J.W. (Joanne W.) | - |
dc.creator | Yu, H. (Herbert) | - |
dc.creator | Amundadottir, L. (Laufey) | - |
dc.creator | Stolzenberg-Solomon, R.Z. (Rachael Z.) | - |
dc.creator | Sampson, J. (Joshua) | - |
dc.creator | Kraft, P. (Peter) | - |
dc.creator | Schumacher, F. (Fredrick) | - |
dc.creator | Stram, D. (Daniel) | - |
dc.creator | Savage, S.A. (Sharon A.) | - |
dc.creator | Mirabello, L. (Lisa) | - |
dc.creator | Rothman, N. (Nathaniel) | - |
dc.creator | Andrulis, I.L. (Irene L.) | - |
dc.creator | Wunder, J.S. (Jay S.) | - |
dc.creator | Patiño-García, A. (Ana) | - |
dc.creator | Sierrasesumaga, L. (Luis) | - |
dc.creator | Barkauskas, D.A. (Donald A.) | - |
dc.creator | Chung, C.C. (Charles C.) | - |
dc.creator | Gorlick, R.G. (Richard G.) | - |
dc.creator | Purdue, M. (Mark) | - |
dc.creator | Chow, W.H. (Wong-Ho) | - |
dc.creator | Moore, L.E. (Lee E.) | - |
dc.creator | Perez-Jurado, L.A. (Luis A.) | - |
dc.creator | Schwartz, K.L. (Kendra L.) | - |
dc.creator | Davis, F.G. (Faith G.) | - |
dc.creator | Hsing, A.W. (Ann W.) | - |
dc.creator | Berndt, S.I. (Sonja I.) | - |
dc.creator | Black, A. (Amanda) | - |
dc.creator | Wentzensen, N. (Nicolas) | - |
dc.creator | Kovaks, J. (Joseph) | - |
dc.creator | Brinton, L.A. (Louise A.) | - |
dc.creator | Lissowska, J. (Jolanta) | - |
dc.creator | Peplonska, B. (Beata) | - |
dc.creator | Chanock, S.J. (Stephen J.) | - |
dc.creator | McGlynn, K.A. (Katherine A.) | - |
dc.date.accessioned | 2014-08-19T08:04:44Z | - |
dc.date.available | 2014-08-19T08:04:44Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet. 2012 May 6;44(6):651-8. | es_ES |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36328 | - |
dc.description.abstract | In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/201663 | - |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Neoplasms/genetics | es_ES |
dc.subject | Chromosome Aberrations | es_ES |
dc.subject | Mosaicism | es_ES |
dc.subject | Aging/genetics | es_ES |
dc.title | Detectable clonal mosaicism and its relationship to aging and cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1038/ng.2270 | es_ES |
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