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DC Field | Value | Language |
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dc.creator | Cunha-Ferreira, R.M.C. (Roque M. C.) da | - |
dc.creator | Monreal, J.I. (José Ignacio) | - |
dc.creator | Villa-Elizaga, I. (Ignacio) | - |
dc.date.accessioned | 2014-09-29T11:06:13Z | - |
dc.date.available | 2014-09-29T11:06:13Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | da Cunha Ferreira RM, Marquiegui IM, Elizaga IV. Teratogenicity of zinc deficiency in the rat: study of the fetal skeleton. Teratology. 1989 Feb;39(2):181-94. | es_ES |
dc.identifier.issn | 0040-3709 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36764 | - |
dc.description.abstract | Zinc deficiency (ZD) is teratogenic in rats, and fetal skeletal defects are prominent. This study identifies fetal skeletal malformations that affect calcified and non-calcified bone tissue as a result of gestational zinc deficiency in rats, and it assesses the effect of maternal ZD in fetal bone calcification. Pregnant Sprague-Dawley rats (180-250 g) were fed 1) a control diet (76.4 micrograms Zn/g diet) ad libitum (group C), 2) a zinc-deficient diet (0 microgram/g) ad libitum (group ZD), or 3) the control diet pair-fed to the ZD rats (group PF). On day 21 of gestation, laparotomies were performed. Fetuses were weighed, examined for external malformations, and stained in toto with a double-staining technique for the study of skeletal malformations. Maternal and fetal tissues were used for Zn, Mg, Ca, and P determinations. Gross external malformations were present in 97% of the ZD fetuses. No external malformations were found in fetuses from groups C and PF. Ninety-one percent of cleared ZD fetuses had multiple skeletal malformations, whereas only 3% of the fetuses of group PF had skeletal defects; no skeletal malformations were found in fetuses from group C. Some of the skeletal malformations described in the ZD fetuses, mainly affecting non-calcified bone, were not mentioned in previous reports, thus stressing the importance of using double-staining techniques. Examination of stained fetuses and counting of ossification centers revealed important calcification defects in ZD fetuses. These effects were confirmed by lower Ca and P concentrations in fetal bone with alteration of the Ca:P ratio. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Bone and Bones/abnormalities | es_ES |
dc.subject | Zinc/deficiency | es_ES |
dc.subject | Rats | es_ES |
dc.subject | Congenital Abnormalities/etiology | es_ES |
dc.title | Teratogenicity of zinc deficiency in the rat: study of the fetal skeleton | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
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