Effects of a new dietary strategy in the treatment of the metabolic syndrome: the RESMENA diet

Abstract

This study presents a new dietary strategy, the RESMENA diet, to combat the comorbidities of the MetS and compares it with following a diet based on the AHA guidelines. The RESMENA diet proved to be more effective throughout a self-control period, where the participants had to apply on their own previous acquired dietary habits, regarding body composition, especially central obesity, and by reducing transaminase levels and maintaining uric acid and serum glucose levels in patients with MetS. Among people suffering MetS with hyperglycaemia, the RESMENA diet showed more benefits than the AHA diet concerning android fat mass reduction and improvement of the general oxidative stress status. Moreover, this investigation evidenced how fibre, TAC, vitamin C, tocopherols, lycopene and fruits are the dietary components that most contributed to improve the MetS related parameters. Furthermore, a link between the recently discovered myokine irisin and several lipid profile biomarkers was reported, suggesting a response of this myokine to atherogenic burdens or a resistance phenomenon. Finally, different dietary antioxidants were proposed to enhance the PON1 ARE activity by epigenetic regulation, lowering the PON1 gene methylation levels.