Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report
Keywords: 
GLUT12
Cancer cell lines
Spheroid
Immunohistochemistry
Glycolytic metabolism
Issue Date: 
2015
Publisher: 
Ivyspring International Publisher
ISSN: 
1837-9664
Citation: 
Pujol-Gimenez J, Pérez-de-Heredia F, Idoate MA, Airley R, Lostao MP, Evans AR. Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report. J Cancer 2015;6(2):139–143
Abstract
Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.

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