Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Pujol-Gimenez, J. (Jonai) | - |
dc.creator | Perez-de-Heredia, F. (Fátima) | - |
dc.creator | Idoate, M.A. (Miguel Ángel) | - |
dc.creator | Airley, R. (Rachel) | - |
dc.creator | Lostao, M.P. (María Pilar) | - |
dc.creator | Evans, A.R. (Andrew Robert) | - |
dc.date.accessioned | 2015-01-26T16:50:26Z | - |
dc.date.available | 2015-01-26T16:50:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Pujol-Gimenez J, Pérez-de-Heredia F, Idoate MA, Airley R, Lostao MP, Evans AR. Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report. J Cancer 2015;6(2):139–143 | es_ES |
dc.identifier.issn | 1837-9664 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37370 | - |
dc.description.abstract | Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Ivyspring International Publisher | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | GLUT12 | es_ES |
dc.subject | Cancer cell lines | es_ES |
dc.subject | Spheroid | es_ES |
dc.subject | Immunohistochemistry | es_ES |
dc.subject | Glycolytic metabolism | es_ES |
dc.title | Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.7150/jca.10429 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.