Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Burguete, A. (Asunción) | - |
dc.creator | Estevez, Y. (Yannick) | - |
dc.creator | Castillo, D. (Denis) | - |
dc.creator | Gonzalez, G. (Germán) | - |
dc.creator | Raquel | - |
dc.creator | Solano, B. (Beatriz) | - |
dc.creator | Vicente, E. (Esther) | - |
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.creator | Sauvain, M. (Michel) | - |
dc.creator | Deharo, E. (Eric) | - |
dc.date.accessioned | 2015-02-23T16:35:52Z | - |
dc.date.available | 2015-02-23T16:35:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Burguete A, Estevez Y, Castillo D, González G, Villar R, Solano B, et al. Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives. Mem Inst Oswaldo Cruz. Dec 2008;103(8):778-780 | es_ES |
dc.identifier.issn | 0074-0276 | - |
dc.identifier.uri | https://hdl.handle.net/10171/37636 | - |
dc.description.abstract | A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships demonstrated the importance of a radical methoxy at position R3', R4' and R5'. (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-1,4-dioxy-quinoxalin-2-yl)-propenone was the most active. Cytotoxicity on macrophages revealed that this product was almost six times more active than toxic. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Quinoxaline | es_ES |
dc.subject | Anti-leishmanial | es_ES |
dc.subject | Structure-activity | es_ES |
dc.subject | Leishmaniasis | es_ES |
dc.title | Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | http://dx.doi.org/10.1590/S0074-02762008000800006 | es_ES |
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