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dc.creatorAjona, D. (Daniel)-
dc.creatorRazquin, C. (Cristina)-
dc.creatorPastor, M.D. (María Dolores)-
dc.creatorPajares, M.J. (María José)-
dc.creatorGarcia, J. (Javier)-
dc.creatorCardenal, F. (F.)-
dc.creatorFleischhacker, M. (M.)-
dc.creatorLozano, M.D. (María Dolores)-
dc.creatorZulueta, J. (Javier)-
dc.creatorSchmidt, B. (Bernd)-
dc.creatorNadal, E. (Ernest)-
dc.creatorPaz-Ares, L. (Luis)-
dc.creatorMontuenga-Badia, L.M. (Luis M.)-
dc.creatorPio, R. (Rubén)-
dc.date.accessioned2015-05-05T14:39:01Z-
dc.date.available2015-05-05T14:39:01Z-
dc.date.created2015-
dc.date.issued2015-
dc.identifier.citationAjona D, Razquin C, Pastor MD, Pajares MJ, Garcia J, Cardenal F, et al. Elevated levels of the complement activation product c4d in bronchial fluids for the diagnosis of lung cancer. PLoS One. 2015 Mar 23;10(3):e0119878.es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10171/38241-
dc.description.abstractMolecular markers in bronchial fluids may contribute to the diagnosis of lung cancer. We previously observed a significant increase of C4d-containing complement degradation fragments in bronchoalveolar lavage (BAL) supernatants from lung cancer patients in a cohort of 50 cases and 22 controls (CUN cohort). The present study was designed to determine the diagnostic performance of these complement fragments (hereinafter jointly referred as C4d) in bronchial fluids. C4d levels were determined in BAL supernatants from two independent cohorts: the CU cohort (25 cases and 26 controls) and the HUVR cohort (60 cases and 98 controls). A series of spontaneous sputum samples from 68 patients with lung cancer and 10 controls was also used (LCCCIO cohort). Total protein content, complement C4, complement C5a, and CYFRA 21-1 were also measured in all cohorts. C4d levels were significantly increased in BAL samples from lung cancer patients. The area under the ROC curve was 0.82 (95%CI = 0.71-0.94) and 0.67 (95%CI = 0.58-0.76) for the CU and HUVR cohorts, respectively. In addition, unlike the other markers, C4d levels in BAL samples were highly consistent across the CUN, CU and HUVR cohorts. Interestingly, C4d test markedly increased the sensitivity of bronchoscopy in the two cohorts in which cytological data were available (CUN and HUVR cohorts). Finally, in the LCCCIO cohort, C4d levels were higher in sputum supernatants from patients with lung cancer (area under the ROC curve: 0.7; 95%CI = 0.56-0.83). In conclusion, C4d is consistently elevated in bronchial fluids from lung cancer patients and may be used to improve the diagnosis of the disease.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/258677-
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLung canceres_ES
dc.subjectBronchial fluidses_ES
dc.titleElevated levels of the complement activation product c4d in bronchial fluids for the diagnosis of lung canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.editorial.noteAttribution 4.0 International (CC BY 4.0)es_ES
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0119878es_ES

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