Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Erro-Aguirre, M.E (María Elena) | - |
dc.creator | Zelaya, M.V. (María Victoria) | - |
dc.creator | Sanchez-Ruiz-de-Gordoa, J. (Javier) | - |
dc.creator | Tuñon, M.T. (María Teresa) | - |
dc.creator | Lanciego, J.L. (José Luis) | - |
dc.date.accessioned | 2015-05-11T16:41:13Z | - |
dc.date.available | 2015-05-11T16:41:13Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Erro-Aguirre ME, Zelaya MV, Sánchez-Ruiz-de-Gordoa J, Tuñón MT, Lanciego JL. Midbrain catecholaminergic neurons co-express a-synuclein and tau in progressive supranuclear palsy. Front Neuroanat. 2015 Mar;9(25) | es_ES |
dc.identifier.issn | 1662-5129 | - |
dc.identifier.uri | https://hdl.handle.net/10171/38278 | - |
dc.description.abstract | Objective: To analyze the frequency and distribution of a-synuclein deposits in progressive supranuclear palsy (PSP). Methods: The brains of 25 cases of pathologically confirmed PSP were evaluated with immunohistochemistry for a-synuclein and tau. Multiple immunofluorescent stains were applied to analyze the expression of tau and a-synuclein aggregates in catecholaminergic neurons. Patients’ clinical symptoms were retrospectively recorded. Results: Deposits a-synuclein in the form of typical Lewy bodies (LBs) were only found in two PSP cases (8%) that fulfilled the clinical subtype of PSP known as Richardson’s syndrome (RS). LBs were present in the locus ceruleus (LC), substantia nigra pars compacta (SNc), basal forebrain, amygdala and cingulated cortex in a distribution mimicking that of Parkinson’s disease (PD). Triple-immunolabeling revealed co-expression of a-synuclein and tau proteins in some tyrosine hydroxilase (TH)-positive neurons of the LC and SNc. Conclusions: There is no apparent clinical correlation between the presence of LBs in PSP. Tau protein co-aggregate with a-synuclein in catecholaminergic neurons of PSP brains suggesting a synergistic interaction between the two proteins. This is in keeping with the current view of neurodegenerative disorders as “misfolded protein diseases”. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Neurodegenerative diseases | es_ES |
dc.subject | Atypical parkinsonian disorders | es_ES |
dc.subject | Lewy bodies | es_ES |
dc.subject | Multiple immunolabeling techniques | es_ES |
dc.subject | Substantia nigra | es_ES |
dc.title | Midbrain catecholaminergic neurons co-express a-synuclein and tau in progressive supranuclear palsy | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.editorial.note | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3389/fnana.2015.00025 | es_ES |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.