Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
Keywords: 
Non-Covalent Hydrogels
Cyclodextrins
Poloxamines
Proteins
Materias Investigacion::Química
Issue Date: 
2014
Publisher: 
Elsevier
OpenAIRE: 
Gobierno de Navarra 348 grant (Plan de Formación y de I+D).
Ministerio de Ciencia e Innovación (project 347 MAT2007-65752)
Universidad de Navarra (PIUNA).
ISSN: 
0144-8617
Editorial note: 
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation: 
Larrañeta E, Isasi JR. Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins. Carbohydr Polym 2014;102:674-681
Abstract
Different types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used. For each of their four diblock arms, direct Tetronic 904 presents PEO outer blocks while in reverse Tetronic 90R4 the hydrophilic PEO blocks are the inner ones. These gels were prepared by combining α-CD and poloxamine aqueous solutions. The physicochemical properties of these systems depend on several factors such as the structure of the block copolymers and the Tetronic/α-CD ratio. These gels were characterized using differential scanning calorimetry (DSC), viscometry and X-ray diffraction measurements. The 90R4 gels present a consistency that makes them suitable for sustained drug delivery. The resulting gels were easily eroded: these complexes were dismantled when placed in a large amount of water, so controlled release of entrapped large molecules such as proteins (Bovine Serum Albumin, BSA) is feasible and can be tuned by varying the copolymer/CD ratio.

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