Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Persico, A. M. (Antonio M.) | - |
dc.creator | Mengual, E. (Elisa) | - |
dc.creator | Moessner, R. (Rainald) | - |
dc.creator | Hall, S. F. (Scott F.) | - |
dc.creator | Revay, R. S. (Randal S.) | - |
dc.creator | Sora, I. (Ichiro) | - |
dc.creator | Arellano, J. (Jon) | - |
dc.creator | De-Felipe, J. (Javier) | - |
dc.creator | Gimenez-Amaya, J.M. (José Manuel) | - |
dc.creator | Conciatori, M. (Monica) | - |
dc.creator | Marino, R. (Ramona) | - |
dc.creator | Baldi, A. (Alfonso) | - |
dc.creator | Cabib, S. (Simona) | - |
dc.creator | Pascucci, T. (Tiziana) | - |
dc.creator | Uhl, G. R. (George R.) | - |
dc.creator | Murphy, D. L. (Dennis L.) | - |
dc.creator | Lesch, K. P. (K. Peter) | - |
dc.creator | Keller, F. (Flavio) | - |
dc.date.accessioned | 2017-04-26T07:42:40Z | - |
dc.date.available | 2017-04-26T07:42:40Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Persico A.M., Mengual E., Moessner R., Hall S.F., Revay R. S., Sora I., et al. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. The journal of neuroscience, 2001Sep, 21(17):6862-6873. | es_ES |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | https://hdl.handle.net/10171/43256 | - |
dc.description.abstract | Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). 5-HTT knock-out (ko) mice reveal a nearly complete absence of 5-HT in the cerebral cortex by immunohistochemistry, and of barrels, both at P7 and adulthood. Quantitative electron microscopy reveals that 5-HTT ko affects neither the density of synapses nor the length of synaptic contacts in layer IV. VMAT2 ko mice, completely lacking activity-dependent vesicular release of monoamines including 5-HT, also show a complete lack of 5-HT in the cortex but display largely normal barrel fields, despite sometimes markedly reduced postnatal growth. Transient 5-HTT expression is thus required for barrel pattern formation, whereas activity-dependent vesicular 5-HT release is not. | es_ES |
dc.description.sponsorship | This work was funded by the European Community Biomed Program (Grant BM H4-C T96-0730), Fondation Jerôme Lejeune, Fondazione Carisal, the German Federal Ministry for Education and Science (BMBF) (Grant 01 K S 9603), and the Deutsche Forschungsgemeinschaft (Grant Le 629/3-2). K .P.L. is supported by the Hermann and Lilly Schilling Foundation. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Society for Neuroscience | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Anatomía | es_ES |
dc.subject | Barrel | es_ES |
dc.subject | Homologous recombination | es_ES |
dc.subject | Knock-out | es_ES |
dc.subject | Monoamine | es_ES |
dc.subject | P-chlorophenylalanine | es_ES |
dc.subject | Serotonin | es_ES |
dc.subject | Serotonin transporter | es_ES |
dc.subject | Vesicular monoamine transporter | es_ES |
dc.subject | GABA transporter | es_ES |
dc.subject | Whisker | es_ES |
dc.title | Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.jneurosci.org/content/21/17/6862J | es_ES |
dc.description.note | Creative Commons Attribution-Noncommercial-ShareAlike3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0) | es_ES |
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