Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Acanda-de-la-Rocha, A.M. (Arlet María) | - |
dc.creator | Lopez-Bertoni, H. (Hernando) | - |
dc.creator | Guruceaga, E. (Elizabeth) | - |
dc.creator | Gonzalez-Huarriz, M. (Marisol) | - |
dc.creator | Martinez-Velez, N. (Naiara) | - |
dc.creator | Xipell, E. (Enric) | - |
dc.creator | Fueyo, J. (Juan) | - |
dc.creator | Gomez-Manzano, C. (Candelaria) | - |
dc.creator | Alonso-Roldán, M.M. (Marta María) | - |
dc.date.accessioned | 2018-02-13T12:32:27Z | - |
dc.date.available | 2018-02-13T12:32:27Z | - |
dc.date.issued | 2016-09-16 | - |
dc.identifier.citation | Acanda-de-la-Rocha, A.M. (Arlet María); Lopez-Bertoni, H. (Hernando); Guruceaga, E. (Elizabeth); et al. "Analysis of SOX2-regulated transcriptome in glioma stem cells". PlosOne. 11 (9), 2016,1-20 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/47448 | - |
dc.description.abstract | Introduction Glioblastoma is the most malignant brain tumor in adults and is associated with poor sur- vival despite multimodal treatments. Glioma stem-like cells (GSCs) are cells functionally defined by their self-renewal potential and the ability to reconstitute the original tumor upon orthotopic implantation. They have been postulated to be the culprit of glioma chemo- and radio-resistance ultimately leading to relapse. Understanding the molecular circuits govern- ing the GSC compartment is essential. SOX2, a critical transcription regulator of embryonic and neural stem cell function, is deregulated in GSCs however; the precise molecular path- ways regulated by this gene in GSCs remain poorly understood. Results We performed a genome-wide analysis of SOX2-regulated transcripts in GSCs, using a microarray. We identified a total of 2048 differentially expressed coding transcripts and 261 non-coding transcripts. Cell adhesion and cell-cell signaling are among the most enriched terms using Gene Ontology (GO) classification. The pathways altered after SOX2 down- modulation includes multiple cellular processes such as amino-acid metabolism and inter- cellular signaling cascades. We also defined and classified the set of non-coding transcripts differentially expressed regulated by SOX2 in GSCs, and validated two of them. Conclusions We present a comprehensive analysis of the transcriptome controlled by SOX2 in GSCs, gaining insights in the understanding of the potential roles of SOX2 in glioblastoma. | es_ES |
dc.description.sponsorship | European Union, Instituto de Salud Carlos III, los Fondos Feder Europeos, Spanish Ministry of Economy and competitiveness, L‘OREAL-Unesco Foundation, Department of Health of the Government of Navarra, The Basque Foundation for Health Research, Fundación Caja Navarra, the Friends of the University of Navarra Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Analysis of SOX2-regulated transcriptome in glioma stem cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0163155 | - |
Files in This Item:
Statistics and impact
Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.