Búsqueda de nuevas moléculas relacionadas con el metabolismo del RNA. Valoración de su papel en carcinogénesis pulmonar

Abstract

Lung cancer is one of the most common diseases in Western countries, and is the malignancy with the highest mortality. A better understanding of the molecular mechanisms associated with lung carcinogenesis is needed to improve survival rates. In this work we searched for genes related to RNA metabolism with an altered expression in non-small cell lung cancer (NSCLC). We used available data from previous microarray studies, which compared gene expression between normal and lung cancer tissues. We found mRNA expression differences between normal and tumor samples in several genes. Results were validated both in primary lung tumors and cell lines. We selected two of the genes for further studies, ADARB1 and PTB.