Full metadata record
DC Field | Value | Language |
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dc.creator | Rodriguez-Otero, P. (Paula) | - |
dc.creator | Mateos, M.V. (María Victoria) | - |
dc.creator | Martínez-López, J. (Joaquín) | - |
dc.creator | Hernandez, M.T. (Miguel Teodoro) | - |
dc.creator | Ocio, E.M. (Enrique M.) | - |
dc.creator | Rosiñol, L. (Laura) | - |
dc.creator | Martínez, R. (Rafael) | - |
dc.creator | Teruel, A.I. (Ana Isabel) | - |
dc.creator | Gutierrez, N.C. (Norma C.) | - |
dc.creator | Bargay, J. (Joan) | - |
dc.creator | Bengoechea, E. (Enrique) | - |
dc.creator | Gonzalez, Y. (Yolanda) | - |
dc.creator | Pérez-de-Oteyza, J. (Jaime) | - |
dc.creator | Gironella, M. (Mercedes) | - |
dc.creator | Nuñez-Cordoba, J.M. (Jorge M.) | - |
dc.creator | Encinas, C. (Cristina) | - |
dc.creator | Martin, J. (Jesus) | - |
dc.creator | Cabrera, C. (Carmen) | - |
dc.creator | Palomera, L. (Luis) | - |
dc.creator | Arriba, F. (Felipe) de | - |
dc.creator | Cedena, M.T. (María Teresa) | - |
dc.creator | Puig, N. (Noemí) | - |
dc.creator | Oriol, A. (Albert) | - |
dc.creator | Paiva, B. (Bruno) | - |
dc.creator | Bladé, J. (Joan) | - |
dc.creator | Lahuerta, J.J. (Juan José) | - |
dc.creator | San-Miguel, J.F. (Jesús F.) | - |
dc.date.accessioned | 2019-05-15T11:50:21Z | - |
dc.date.available | 2019-05-15T11:50:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Rodríguez-Otero, P. (Paula); Mateos, M. V.; Martinez-Lopez, J.; et al. "Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature". Blood Cancer Journal. 9 (4), 2019, 36 | es |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | https://hdl.handle.net/10171/56822 | - |
dc.description.abstract | Disease control at 5 years would be a desirable endpoint for elderly multiple myeloma (MM) patients, but biomarkers predicting this are not defined. Therefore, to gain further insights in this endpoint, a population of 498 newly diagnosed transplant-ineligible patients enrolled in two Spanish trials (GEM2005MAS65 and GEM2010MAS65), has been analyzed. Among the 435 patients included in this post-hoc study, 18.6% remained alive and progression free after 5 years of treatment initiation. In these patients, overall survival (OS) rate at 10 years was 60.8% as compared with 11.8% for those progressing within the first 5 years. Hemoglobin (Hb) >= 12 g/dl (OR 2.74, p = 0.001) and MGUS-like profile (OR 4.18, p = 0.005) were the two baseline variables associated with long-term disease-free survival. Upon including depth of response (and MRD), Hb >= 12 g/dl (OR 2.27) and MGUS-like signature (OR 7.48) retained their predictive value along with MRD negativity (OR 5.18). This study shows that despite the use of novel agents, the probability of disease control at 5 years is still restricted to a small fraction (18.6%) of elderly MM patients. Since this endpoint is associated with higher rates of OS, this study provides important information about diagnostic and post-treatment biomarkers helpful in predicting the likelihood of disease control at 5 years. | - |
dc.description.sponsorship | This study was supported by the Centro de Investigación Biomédica en Red —Área de Oncología— del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369 and CB16/12/00377), Instituto de Salud Carlos III / Subdirección General de Investigación Sanitaria (FIS no. PS09/01897/01370, PI12/01761, PI12/02311,PI13/01469, PI14/01867, G03/136, CD13/00340), Asociación Española Contra el Cáncer (GCB120981SAN) and the European Research Council (ERC) 2015 Starting Grant (MYELOMANEXT). | - |
dc.language.iso | en | - |
dc.relation | info:eu-repo/grantAgreement/EC/ERC/680200-MYELOMANEXT | - |
dc.rights | info:eu-repo/semantics/openAccess | - |
dc.title | Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature | - |
dc.type | info:eu-repo/semantics/article | - |
dc.description.note | This article is licensed under a Creative Commons Attribution 4.0 International License (CCBY) | - |
dc.identifier.doi | 10.1038/s41408-019-0176-x | - |
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