Trehalose-based siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
Keywords: 
Materias Investigacion::Farmacia
Materias Investigacion::Química
Issue Date: 
2019
Publisher: 
Royal Society of Chemistry
ISSN: 
1359-7345
Note: 
This article is licensed under a Creative Commons Atribution 3.0 unported
Citation: 
Carbajo-Gordillo, A.I. (Ana I.); Rodríguez-Lavado, J. (Julio); Jiménez-Blanco, J.L. (José Luis); et al. "Trehalose-based siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties". Chemical communications. 55, 2019, 8227 - 8230
Abstract
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared fromthe disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

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